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TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states [DNA methylation array - d10earclips_2nd cohort]

ABSTRACT: TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states [DNA methylation array - d10earclips_2nd cohort]

PROVIDER: PRJNA1093046 | ENA |

REPOSITORIES: ENA

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TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states [DNA methylation array - d10earclips_2nd cohort]

Project description:Mutations in cancer risk genes increase susceptibility, but not all carriers develop cancer. Indeed, while DNA mutations are necessary drivers of cancer, only a small subset of mutated cells go on to cause the disease. To date, the mechanisms underlying individual cancer susceptibility remain unclear. Here, we took advantage of a unique mouse model of intrinsic developmental heterogeneity (Trim28+/D9) to investigate whether early-life epigenetic variation influences cancer susceptibility later in life. We found that heterozygosity of Trim28 is sufficient to generate two distinct early-life epigenetic states associated with differing cancer susceptibility. These developmentally primed states exhibit differential methylation patterns at typically silenced heterochromatin, detectable as early as 10 days of age. The differentially methylated loci are enriched for genes with known oncogenic potential, frequently mutated in human cancers and correlated with poor prognosis. This study provides genetic evidence that intrinsic developmental heterogeneity can prime individual, lifelong cancer susceptibility.

2024-03-29 | GSE262711 | GEO

TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states [DNA methylation array - d10earclips]

2023-09-07 | GSE229030 | GEO

TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states [DNA methylation array - healthyTissues]

2024-03-29 | GSE262712 | GEO

TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states

Project description:TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states

| PRJNA1093044 | ENA

TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states [DNA methylation array - d10earclips]

Project description:TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states [DNA methylation array - d10earclips]

| PRJNA952612 | ENA

TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states [DNA methylation array - healthyTissues]

Project description:TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states [DNA methylation array - healthyTissues]

| PRJNA1093047 | ENA

TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states [RNA-seq - day 10 earclips]

2024-04-02 | GSE263020 | GEO

TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states [RNA-seq - matched healthy and tumor tissues]

2024-04-02 | GSE263021 | GEO

TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states [RNA-seq - day 10 earclips]

Project description:TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states [RNA-seq - day 10 earclips]

| PRJNA1095462 | ENA

TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states [RNA-seq - matched healthy and tumor tissues]

Project description:TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states [RNA-seq - matched healthy and tumor tissues]

| PRJNA1095465 | ENA

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