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Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement [WGBS]

ABSTRACT: Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement [WGBS]

PROVIDER: PRJNA1093469 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28504900_1.fastq.gz	Fastqsanger.gz
	SRR28504900_2.fastq.gz	Fastqsanger.gz
	SRR28504901_1.fastq.gz	Fastqsanger.gz
	SRR28504901_2.fastq.gz	Fastqsanger.gz
	SRR28504902_1.fastq.gz	Fastqsanger.gz

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Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement [WGBS]

Project description:Durability of an antitumor immune response is mediated in part by the persistence of progenitor exhausted CD8 T cells (Tpex). Tpex serve as a source for the pool of effector T cells, and in the absence of their cognate antigen, they are able to preserve their quantity through a process of self-renewal. However, it remains unknown how TCR engagement impacts the self-renewal capacity of Tpex in settings of continued antigen exposure. Here, we used a Lewis lung carcinoma model that elicits an optimal or attenuated TCR signal in CD8 T cells to investigate its effect on Tpex persistence during tumor development. Longitudinal phenotyping and single-cell transcriptomics of tumor-specific T cells revealed that formation of the Tpex reservoir in tumor-draining lymph nodes, and its subsequent replenishment of intratumoral Tpex, is dependent on optimal TCR engagement. Notably, adoptive transfer of optimally primed Tpex into a tumor setting with attenuated TCR stimulation significantly accelerates their terminal differentiation, contrasting to the sustained self-renewal occuring with optimal TCR stimulation. This TCR-reinforced Tpex development and self-renewal is coupled to proximal positioning to dendritic cell niches and epigenetic imprinting that involves increased chromatin accessibility at Egr2 and Tcf1 target loci. Collectively, our study highlights the critical role of TCR engagement in sustaining Tpex during tumor progression

2024-04-05 | GSE262843 | GEO

Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement

Project description:Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement

| PRJNA1093467 | ENA

Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement [ATACseq]

Project description:Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement [ATACseq]

| PRJNA1093468 | ENA

Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement [scRNAseq]

Project description:Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement [scRNAseq]

| PRJNA1093430 | ENA

Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement [CUT&Tag]

Project description:Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement [CUT&Tag]

| PRJNA1093471 | ENA

Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement [ATACseq]

2024-04-05 | GSE262842 | GEO

Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement [scRNAseq]

2024-04-05 | GSE262816 | GEO

Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement [CUT&Tag]

2024-04-05 | GSE262844 | GEO

Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-04-05 | GSE262845 | GEO

Single-cell RNA-seq of human breast tumor samples with exhausted and non-exhausted immune environments

Project description:Fresh human breast tumor tissue was dissociated into single cells and viably frozen. Patient samples were annotated as having an ""exhausted"" or ""non-exhausted"" immune environment based on CyTOF characterization of T cell phenotypes (Wagner et al, Cell 2019). 14 samples (7 exhausted, 7 non-exhausted) were selected for scRNA-seq (without prior cell type enrichment) with the goal to compare the two immune environment types and to comprehensively characterize exhaustion-associated features of the tumor microenvironment.

2023-08-25 | E-MTAB-10607 | biostudies-arrayexpress

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