Project description:This SuperSeries is composed of the following subset Series:; GSE6815: Hyperexpression of Mouse Melanotransferrin on LMTK Cell Line; GSE6816: Hyperexpression of Human Melanotransferrin on SK-N-MC Cell Line; GSE6817: Downregulation of Human Melanotransferrin on SK-Mel-28 Cell Line Experiment Overall Design: Refer to individual Series
Project description:Analysis of transcriptome kinetics of SW1736 thyroid cancer cell line vs SK-MEL-28 melanoma cell line at various times after addition of 2 µM vemurafenib. The hypothesis tested was that SW1736 cells (vemurafenib-refractory) differentially express genes compared to SK-MEL-28 cells (vemurafenib sensitive) that confer resistance to the RAF inhibitor.
Project description:We report differentially expressed genes by DATS exposure in MCF-10A human epithelial cell line and SK-BR-3 human breast cancer cell line
Project description:To understand the molecular features associated with VZV infection in humans, we applied an orthogonal proteomic approach that assayed the interactions between VZV and its host in the neuroblastoma SK-N-BE2 cell line. First, we infected SK-N-BE2 cells with VZV rOka for 48 hours and analysed the induced proteome changes by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Project description:ATAC-seq on human cell line SK-N-SH For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf
Project description:The incidence of TP53 loss-of-function in hepatocellular carcinoma is very high. In order to clarify the gene expression differences induced by the changes of TP53 gene, we used two human hepatocellular carcinoma cell lines, SK-HEP-1 and Hep 3B with TP53 knockdown or overexpression for RNA sequencing . SK-HEP-1 is a TP53 wild-type hepatocellular carcinoma cell line. Thus, we knockdown TP53 in SK-HEP-1. Hep 3B is a TP53 loss-of-function hepatocellular carcinoma cell line. Thus, we overexpress TP53 in Hep 3B. Results of RNA-seq analysis showed the differences after knocking-down or overexpressing TP53.
