Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: UCE target enrichment of Pachyrhynchus weevils

PROVIDER: PRJNA1099439 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR28753700_1.fastq.gz	Fastqsanger.gz
	SRR28753700_2.fastq.gz	Fastqsanger.gz
	SRR28753701_1.fastq.gz	Fastqsanger.gz
	SRR28753701_2.fastq.gz	Fastqsanger.gz
	SRR28753702_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 276

Similar Datasets

Project description:UCE target enrichment of Peromyscus and Habromys

| PRJNA606805 | ENA

Project description:UCE target enrichment of Symposiachrus monarch flycatchers

| PRJNA698220 | ENA

Cullin-RING ligases target substrates with geometrically optimized catalytic partners

Project description:Cullin-RING ubiquitin ligases (CRLs) control the degradation of a wide landscape of human proteins in combination with ubiquitin-carrying enzymes (UCEs). CRL expansion during evolution is apparent, with a few dozen in yeast that function with a single UCE and as many as 300 in humans that function with at least 8 UCEs. A major unaddressed question is why human CRL buildup has been accompanied by additional UCEs that function with CRLs. Here we demonstrate that human CRLs and UCEs can display specificity, resulting in increased affinity for each other and enhanced rates of ubiquitin transfer to substrates. To uncover the structural basis for CRL-UCE specificity, cryo-EM was performed on a CRL2 subfamily member with substrate receptor subunit FEM1C (CRL2FEM1C) in complex with a proxy for catalytically active UCE. The structure elucidated an extensive CRL-UCE interface that promotes proximity between the UCE active site and CRL2FEM1C-bound substrate. Unanticipated selectivity was also observed between the CRL substrate Lys ubiquitylation sites and the identity of the UCE. CRL-UCE specificity also manifests during targeted protein degradation by affecting the activities of drugs that induce ubiquitylation of neosubstrates. An emerging CRL code is revealed that drives selective formation of CRL-UCE complexes to promote rapid substrate ubiquitylation.

2024-05-22 | PXD043523 | Pride

Project description:How the Easter Egg Weevils Got Their Spots: Phylogenomics Reveals Mullerian Mimicry in Pachyrhynchus (Coleoptera, Curculionidae).

| PRJNA871362 | ENA

Evf2 ultraconserved enhancer long non-coding RNA (UCE lncRNA)-dependent UCE interactions (4Cseq), and cohesin binding, histone methylation and acetylation (ChIPseq) in mouse E13.5 ganglionic eminences

Project description:In this study we used mice lacking Evf2 (Evf2TS/TS) and mice expressing a truncated form of Evf2 (Evf1TS/TS) to determine UCE lncRNA epigenetic and chromosome toplogical control. We used 4Cseq to investigate how Evf2 regulates UCE interactions along chromosome 6 (where Evf2 is expressed). We used ChIpseq to compare histone methylation profiles from Evf2TS/TS and Evf1TS/TS. In addition, we used ChIPseq to determine Evf2-depedent regulation of cohesin subunit binding (SMC1 and SMC3) and histone H3K27acetylation. Together, these data support that Evf2 UCE lncRNA controls chromosome topology over multi-megabse distances, through cohesin binding and effects on histone methylation and acetylation. Also included is the ChIPseq profile of Dlx binding sites in SW (outbred strain of mice) from E13.5 GE.

2018-08-23 | GSE117184 | GEO

Eudyptes pachyrhynchus

Project description:Eudyptes pachyrhynchus

| PRJNA958969 | ENA

Pachyrhynchus weevils

Project description:Comparative phylogeography in the Taiwan-Luzon volcanic belt indicates fast diversification history of Pachyrhynchus weevils (Coleoptera: Curculionidae)

| PRJNA899687 | ENA

Project description:Pronophilina target enrichment

| PRJNA860204 | ENA

Oomycetes

Project description:Oomycetes target enrichment

| PRJNA657516 | ENA

Project description:MinION target enrichment

| PRJEB8285 | ENA