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MRNA profile of PANC-1 treated with CAF-derived Evs

ABSTRACT: mRNA profile of PANC-1 treated with CAF-derived Evs

PROVIDER: PRJNA1100447 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28682439_1.fastq.gz	Fastqsanger.gz
	SRR28682439_2.fastq.gz	Fastqsanger.gz
	SRR28682440_1.fastq.gz	Fastqsanger.gz
	SRR28682440_2.fastq.gz	Fastqsanger.gz
	SRR28682441_1.fastq.gz	Fastqsanger.gz

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mRNA profile of PANC-1 treated with CAF-derived Evs

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RIP sequencing in PANC-1 cells to map the YBX1-binding mRNA of PANC-1 cells treated with CAF-derived Evs

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Project description:Perineural invasion (PNI) is a unique biological feature of pancreatic cancer and is a key cause of pancreatic cancer metastasis, recurrence and poor postoperative survival, but its mechanism is largely unclarified. Clinical sample analysis and endoscopic ultrasonographic elasticity scoring indicated that cancer-associated fibroblasts (CAFs) are closely related to the occurrence of PNI. Furthermore, CAF-derived extracellular vesicles played an extremely important role in PNI in a dorsal root ganglion (DRG) coculture model and sciatic nerve model. Next, we demonstrated that CAFs promoted PNI via extracellular vesicle transmission of PNI-associated transcript (PIAT). To explored the potential mRNA interacted with YBX1, we we performed YBX1 RNA immunoprecipitation–sequencing (RIP-seq).

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