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MRNA expression profiles of oxygen-induced retinopathy (OIR) mouse retinas after knockdown treatment of lncRNA-MM2P

ABSTRACT: mRNA expression profiles of oxygen-induced retinopathy (OIR) mouse retinas after knockdown treatment of lncRNA-MM2P

PROVIDER: PRJNA1100496 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28687683_1.fastq.gz	Fastqsanger.gz
	SRR28687683_2.fastq.gz	Fastqsanger.gz
	SRR28687684_1.fastq.gz	Fastqsanger.gz
	SRR28687684_2.fastq.gz	Fastqsanger.gz
	SRR28687685_1.fastq.gz	Fastqsanger.gz

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mRNA expression profiles of oxygen-induced retinopathy (OIR) mouse retinas after knockdown treatment of lncRNA-MM2P

Project description:The purpose of this study is to investigate the mRNA expression profiles of OIR retinas after knockdown treatment of lncRNA-MM2P. We established an OIR model in C57BL/6J mice. The expression of lncRNA-MM2P in the retinas of OIR mice was knocked down by intravitreal injection of self-complementary adeno-associated virus (scAAV). Retinas of four eyes from two OIR mice were collected as one sample. The control group was treated with control scAAV and named as AAV_NC, the knockdown group was treated with knockdown scAAV and named as AAV_sh. The total RNA was extracted from total of eight samples (four samples each group) for RNA sequencing.

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Project description:We aimed at identifying the regulatory network of Aflibercept in the context of pathological neovascularization by using the oxygen-induced retinopathy mouse model as a surrogate of proliferative diabetic retinopathy Total RNA was collected from entire retinal cups dissected from 50-days old mice subjected to the oxygen-induced retinopathy protocol and subsequently injected with Aflibercept either on postnatal days 13 and 15 (OIR+AFLx2) or on postnatal days 13, 15 and 17. Non-injected OIR littermates (OIR) and age-matched mice housed in normoxic conditions (normoxia) were used as controls.

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