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Sub-optimal paternal diet at the time of mating perturbs maternal adaptations in the late gestation mouse

ABSTRACT: Sub-optimal paternal diet at the time of mating perturbs maternal adaptations in the late gestation mouse

PROVIDER: PRJNA1104197 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28793321_1.fastq.gz	Fastqsanger.gz
	SRR28793321_2.fastq.gz	Fastqsanger.gz
	SRR28793322_1.fastq.gz	Fastqsanger.gz
	SRR28793322_2.fastq.gz	Fastqsanger.gz
	SRR28793323_1.fastq.gz	Fastqsanger.gz

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Sub-optimal paternal diet at the time of mating perturbs maternal adaptations in the late gestation mouse

Project description:Pregnancy represents a stage during which maternal physiology and homeostatic regulation undergo dramatic change and adaptation. The fundamental purpose of these adaptations is to ensure the survival of her offspring through adequate nutrient provision and an environment that is tolerant to the semi-allogenic fetus. While poor maternal diet during pregnancy is associated with perturbed maternal adaptations during pregnancy, the influence of paternal diet on maternal well-being is less clearly-defined. We fed male mice either a control (CD), low protein diet (LPD), a high fat/sugar Western diet (WD) or the LPD or WD supplemented with methyl donors (MD-LPD and MD-WD respectively) for a minimum of 8 weeks prior to mating. Females were culled at day 17 of gestation for the analysis of maternal metabolic, gut, cardiac and bone health. Paternal diet had minimal influences on maternal metabolic status or gut microbiota diversity. However, analysis of the maternal hepatic transcriptome revealed distinct profiles of differential gene expression in response to the diet of the father. Paternal LPD and MD-LPD resulted in differential expression of genes associated with lipid metabolism, transcription, ubiquitin conjugation and immunity in dams, while paternal WD and MD-WD modified the expression of genes associated with ubiquitin conjugation and cardiac morphology. Finally, we observed changes in maternal femur length, volume of trabecular bone, trabecular connectivity, volume of the cortical medullar cavity and thickness of the cortical bone in response to the father’s diets. Our current study demonstrates that poor paternal diet at the time of mating can influence the patterns of maternal metabolism and gestation-associated adaptations to her physiology. Such changes could have significant consequences for the long-term health of his offspring and the mother.

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