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Sequencing of human hepatocellular carcinoma huh7 cell line under the effect of disulfiram [m1A-seq]

ABSTRACT: Sequencing of human hepatocellular carcinoma huh7 cell line under the effect of disulfiram [m1A-seq]

PROVIDER: PRJNA1105569 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28824064_1.fastq.gz	Fastqsanger.gz
	SRR28824064_2.fastq.gz	Fastqsanger.gz
	SRR28824065_1.fastq.gz	Fastqsanger.gz
	SRR28824065_2.fastq.gz	Fastqsanger.gz
	SRR28824066_1.fastq.gz	Fastqsanger.gz

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Sequencing of human hepatocellular carcinoma huh7 cell line under the effect of disulfiram [m1A-seq]

Project description:To detect the altered m1A in human hepatocellular carcinoma huh7 cell line under the condition of disulfiram and contorl.

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Sequencing of human hepatocellular carcinoma huh7 cell line under the effect of disulfiram [transcriptome]

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Transcription profiling of human hepatocellular carincoma-derived cell line Huh7-S33Y with high TCF activity compared to a control Huh7 cell line

Project description:The Wnt signaling pathway is involved in many differentiation events during embryonic development and can lead to tumor formation after aberrant activation of its components. Β-catenin, a cytoplasmic component, plays a major role in the transduction of the canonical wnt/ β-catenin signaling. The aim of this study was to identify novel genes that are regulated by active β-catenin/TCF signaling in hepatocellular carcinoma. We selected and expanded isogenic clones from hepatocellular carcinoma-derived Huh7 cells with high and low β-catenin/TCF activities. We showed that, high TCF activity Huh7 cells lead to bigger and more aggressive tumors when xenografted into nude mice. We used SAGE (Serial Analysis of Gene Expression), genome-wide microarray and in silico promoter analysis in parallel, to compare gene expression between low (basal) and high (transfected) β-catenin/TCF activity clones, those had been xenografted into nude mice. We compared and contrasted SAGE and genome-wide microarray data, in parallel. Finally; after combined analysis, we identified BRI3 and HSF2 as novel targets of Wnt/β-catenin signaling in hepatocellular carcinoma. Experiment Overall Design: High TCF activity Huh7 cell line (Huh7-S33Y) was compared to control Huh7 cell line (Huh7-Vec) by using 10 ug of total RNA isolated from each sample (15 ug of labeled cRNA was hybridized to the arrays). Triplicates are coming from same total RNA extraction.

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Project description:LncRNA and mRNA expression profiling of Hepatocellular carcinoma Huh7 when HINT1 knockdown. HINT1 is a novel tumor suppressor gene, which can regulate the transcription of a variety of cancer-related genes, and its regulation networks is poorly understood in hepatocellular carcinoma. We used the total RNA from siControl and siHINT1 Huh7 cells to analyze the differentially expressed lncRNA and mRNA which were regulated by HINT1, and further explored the ceRNA network that HINT1 may involved.

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Hepatocellular carcinoma Huh7: siHINT1 vs. siControl

Project description:Hepatocellular carcinoma Huh7: siHINT1 vs. siControl

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microRNA expression profiles in CD44- and CD44+ hepatocellular carcinoma HuH7 cells

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