Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [ChIP-Seq]

ABSTRACT: Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [ChIP-Seq]

PROVIDER: PRJNA1106495 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [ChIP-Seq]

Project description:As “effector” cells, B lymphocytes make antibodies. They also regulate immune functions through ligand-receptor interactions. The limited understanding of regulatory roles of B cells prompted us to develop a workflow that profiles B cell ligand and receptor expression, maps in silico interactions involving ligands with high “specificity scores”, validates the function of top ligand-receptor interactions, and unveils transcription regulation of specific ligands. Using this unbiased approach, here we report the regulatory functions of a new subset of murine B cells that express BATF3 as a hallmark transcription factor. BATF3+ B cells, as generated upon B cell activation by innate TLR and adaptive CD40 and IL-21 receptor signals, lose their effector cell function (making class-switched antibodies) while expressing new ligands, most notably cytokine IL-27 and chemokine CXCL10. As elicited by viral infection and immunization, IL-27+CXCL10+ B cells target effector B cells through the IL-27 receptor and, together with IFNg, optimize the antibody response and anti-viral immunity. Also appearing in tumors and retained there through the autocrine CXCL10-CXCR3 interaction, they enhance B cell expression of immune checkpoint PD-L1 and suppress anti-tumor immunity. Thus, we have identified new regulatory B cells and provided a paradigmatic framework to investigate immune cell communications.

2025-08-27 | GSE266272 | GEO

Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [CUT&Tag 1]

Project description:Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [CUT&Tag 1]

| PRJNA1106494 | ENA

Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [RNA-Seq 2]

Project description:Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [RNA-Seq 2]

| PRJNA1106497 | ENA

Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [RNA-Seq 4]

Project description:Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [RNA-Seq 4]

| PRJNA1106500 | ENA

Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [ATAC-Seq 2]

Project description:Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [ATAC-Seq 2]

| PRJNA1106474 | ENA

Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [CUT&Tag 2]

Project description:Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [CUT&Tag 2]

| PRJNA1106493 | ENA

Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [ATAC-Seq 1]

Project description:Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [ATAC-Seq 1]

| PRJNA1105113 | ENA

Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [RNA-Seq 1]

Project description:Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [RNA-Seq 1]

| PRJNA1106489 | ENA

Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [RNA-Seq 3]

Project description:Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [RNA-Seq 3]

| PRJNA1106501 | ENA

Induction of regulatory functions in BATF3+ B cells through ligand-receptor interactions [ATAC-Seq 2]

2025-08-27 | GSE266264 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data