Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Microarray, RNA-seq, and ChIP-seq data of 3T3-L1 cells

ABSTRACT: Microarray, RNA-seq, and ChIP-seq data of 3T3-L1 cells

PROVIDER: PRJNA1106619 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

ZEB1 in 3T3-L1 differentiation (ChIP-seq)

Project description:ZEB1 in 3T3-L1 differentiation (ChIP-seq)

| PRJEB6258 | ENA

Detection of microRNA expression during 3T3-L1 pre-adipocyte differentiation using a custom made microarray chip.

Project description:Differentiation of 3T3-L1 cells into adipocytes involves a highly orchestrated series of events including clonal expansion, growth arrest and terminal differentiation. The mechanisms coordinating these different steps are not yet fully understood. Here we investigated whether micro (mi)RNAs play a role in this process. Microarray analysis was performed to detect miRNA expression during 3T3-L1 preadipocyte differentiation. Several miRNAs, including let-7, were up-regulated during 3T3-L1 adipogenesis. Ectopic introduction of let-7 into 3T3-L1 cells inhibited clonal expansion as well as terminal differentiation. The mRNA encoding high mobility group AT-hook 2 (HMGA2), a transcription factor that regulates growth and proliferation in other contexts, was inversely correlated with let-7 levels during 3T3-L1 cell adipogenesis, and let-7 markedly reduced HMGA2 concentrations. Knockdown of HMGA2 inhibited 3T3-L1 differentiation. These results suggest that let-7 plays an important role in adipocyte differentiation and that it does so in part by targeting HMGA2, thereby regulating the transition from clonal expansion to terminal differentiation.

2009-05-26 | GSE16229 | GEO

Expression data from 3T3-L1 adipogenesis

Project description:3T3-L1 fibroblasts are a commonly used in vitro model for adipogenesis. When induced with hormones, they differentiate into mature fat cells. Here, microarrays were used to study 3T3-L1 adipose differentiation through time. Keywords: time course

2007-01-23 | GSE6794 | GEO

Detection of microRNA expression during 3T3-L1 pre-adipocyte differentiation using a custom made microarray chip.

2010-05-18 | E-GEOD-16229 | biostudies-arrayexpress

3T3-L1: GDE5 Knockdown

Project description:Transcriptional profiling of mouse 3T3-L1 adipocytes. The objective of this study is to explore gene expression profiles of 3T3-L1 adipocytes in response to GDE5 siRNA transfection.

2016-12-31 | GSE83644 | GEO

ZEB1 in 3T3-L1 differentiation (ChIP-seq)

Project description:We aimed to characterise genome-wide ZEB1 binding pattern in 3T3-L1 cells at distinct timepoints of adipogenic differentiation (days -2, 0, 2 and 4). We performed replicate experiments at days -2 and 0 and single experiments at days 2 and 4.

2014-09-17 | E-MTAB-2537 | biostudies-arrayexpress

Expression data from SETD5-expressing 3T3-L1 cells ChIP-seq of H3K27ac, H3K4me1, and SETD5 in 3T3-L1 preadipocytes.

Project description:Expression data from SETD5-expressing 3T3-L1 cells ChIP-seq of H3K27ac, H3K4me1, and SETD5 in 3T3-L1 preadipocytes.

| PRJNA762074 | ENA

Expression data from Fbxl10 overexpressing 3T3-L1 cells

Project description:Target genes of Fbxl10 during 3T3-L1 adipogenesis was analyzed 3T3-L1 cells overexpressing Fbxl10 using retrovirus system containing LTR promoter were differentiated and RNA was extracted at day 2 of differentiation

2015-03-04 | E-GEOD-64154 | biostudies-arrayexpress

Expression data from SETD5-expressing 3T3-L1 cells.

Project description:SETD5 target genes in 3T3-L1 cells were analyzed.

2021-10-25 | GSE183845 | GEO

Expression data from Fbxl10 overexpressing 3T3-L1 cells

Project description:Target genes of Fbxl10 during 3T3-L1 adipogenesis was analyzed

2015-03-04 | GSE64154 | GEO