Project description:The skin is the body’s largest and outermost barrier tissue. Whether environmental exposures reinforce barrier resilience remains poorly understood. Here, we show that xenobiotic-induced retroelement-specific immunity enhances tissue repair; more specifically, mild detergent exposure promotes the reactivation of defined retroelements, and retroelement-specific CD8+ responses, in a Langerhans cell-dependent manner. This discrete population of retroelement-specific CD8 T cells are recruited to the skin, where they develop as tissue-resident cells and are enriched for genes associated with wound repair. Upon injury, retroelement-specific CD8+ T cells significantly accelerate wound repair via IL-17A. Collectively, this work demonstrates that tonic environmental exposures promote the accumulation of tissue-resident retroelement-specific T cells that preemptively set the tissue for maximal resilience to barrier breaches.

2025-05-01 | GSE266528 | GEO

Adaptive immunity to retroelements promotes barrier integrity [bulk_whole_tissue]

2025-05-01 | GSE266527 | GEO

Adaptive immunity to retroelements promotes barrier integrity [bulk_CD8]

2025-05-01 | GSE266538 | GEO

Adaptive immunity to retroelements promotes barrier integrity [bulk_DC_KC_LC]

2025-05-01 | GSE266531 | GEO

Adaptive immunity to retroelements promotes barrier integrity.

Project description:Maintenance of tissue integrity is a requirement of host survival. This mandate is of prime importance at barrier sites that are constitutively exposed to the environment. Here, we show that exposure of the skin to non-inflammatory xenobiotics promotes tissue repair; more specifically, mild detergent exposure promotes the reactivation of defined retroelements leading to the induction of retroelement-specific CD8+ T cells. These T cell responses are Langerhans cell dependent and establish tissue residency within the skin. Upon injury, retroelement-specific CD8+ T cells significantly accelerate wound repair via IL-17A. Collectively, this work demonstrates that tonic environmental exposures and associated adaptive responses to retroelements can be coopted to preemptively set the tissue for maximal resilience to injury.

| S-EPMC11326312 | biostudies-literature

Mus musculus musculus strain:C57BL/6

Project description:Adaptive immunity to retroelements maintains barrier integrity

| PRJNA1106434 | ENA

PARP15 promotes vascular barrier integrity in inflammation

Project description:PARP15 promotes vascular barrier integrity in inflammation

| PRJNA989163 | ENA