Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Necroptosis enhances “Don’t eat me” signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis [scRNA-seq]

ABSTRACT: Necroptosis enhances “Don’t eat me” signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis [scRNA-seq]

PROVIDER: PRJNA1107954 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR28902621_1.fastq.gz	Fastqsanger.gz
	SRR28902621_2.fastq.gz	Fastqsanger.gz
	SRR28902622_1.fastq.gz	Fastqsanger.gz
	SRR28902622_2.fastq.gz	Fastqsanger.gz
	SRR28902623_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Necroptosis enhances “Don’t eat me” signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis

Project description:Necroptosis enhances “Don’t eat me” signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis

| PRJNA1044126 | ENA

Necroptosis enhances 'Don’t eat me' signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis [THP1-derived macrophages]

Project description:Necroptosis enhances 'Don’t eat me' signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis [THP1-derived macrophages]

| PRJNA1092539 | ENA

KRAS Inhibition Activates an Actionable CD24 “Don’t Eat Me” Signal in Pancreatic Cancer

Project description:KRAS Inhibition Activates an Actionable CD24 “Don’t Eat Me” Signal in Pancreatic Cancer

| PRJNA1305286 | ENA

KRAS Inhibition Activates an Actionable CD24 “Don’t Eat Me” Signal in Pancreatic Cancer

Project description:KRAS Inhibition Activates an Actionable CD24 “Don’t Eat Me” Signal in Pancreatic Cancer

| PRJNA1294741 | ENA

KRAS Inhibition Activates an Actionable CD24 “Don’t Eat Me” Signal in Pancreatic Cancer

Project description:KRASG12C inhibitors (G12Ci) have produced encouraging, albeit modest and transient, clinical benefit in pancreatic ductal adenocarcinoma (PDAC). Identifying and targeting resistance mechanisms to G12Ci treatment is therefore crucial. To better understand the function of KRASG12C and possible G12Ci bypass mechanisms, we developed an autochthonous KRASG12C-driven PDAC model. Compared to the classical KRASG12D PDAC model, the G12C model exhibits slower tumor growth, yet similar histopathological and molecular features. Aligned with clinical experience, G12Ci treatment of KRASG12C tumors produced modest impact despite stimulating a ‘hot’ tumor immune microenvironment. Immunoprofiling revealed that CD24, a ‘don’t eat me’ signal, is significantly upregulated on cancer cells upon G12Ci treatment. Blocking CD24 enhanced macrophage phagocytosis of cancer cells and significantly sensitized tumors to G12Ci treatment. Similar findings were observed in KRASG12D-driven PDAC. Together, this study reveals common and distinct oncogenic KRAS allele-specific biology and identifies a clinically actionable adaptive mechanism that may improve the efficacy of oncogenic KRAS inhibitor therapy in PDAC.

2025-08-28 | GSE305316 | GEO

KRAS Inhibition Activates an Actionable CD24 “Don’t Eat Me” Signal in Pancreatic Cancer

2025-09-03 | GSE303279 | GEO

Necroptosis enhances “Don’t eat me” signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis

Project description:We delved into the consequences of METs formation. We treated wild-type PANC-1 with METs-containing CM and performed RNA-seq.

2024-05-06 | GSE248494 | GEO

Necroptosis enhances “Don’t eat me” signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis [scRNA-seq]

Project description:We delved into the consequences of C57BL/6 orthotopic model injected with KPC cells with Vector/MLKL overexpression

2024-05-06 | GSE266613 | GEO

Necroptosis enhances 'Don’t eat me' signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis [THP1-derived macrophages]

Project description:We delved into the consequences of macrophages that co-cultured with PDAC cells with Vector/MLKL overexpression. We treated THP1 derived macrophages with PANC1 cells with Vector/MLKL overexpression.

2024-05-06 | GSE262562 | GEO

KRAS inhibition activates an actionable CD24 "Don't eat me" signal in pancreatic cancer

2025-09-04 | GSE307209 | GEO