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Transgenerational inheritance of diabetes susceptibility in male offspring with maternal hyperandrogenism [WGBS]

ABSTRACT: Transgenerational inheritance of diabetes susceptibility in male offspring with maternal hyperandrogenism [WGBS]

PROVIDER: PRJNA1108291 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28919723_1.fastq.gz	Fastqsanger.gz
	SRR28919723_2.fastq.gz	Fastqsanger.gz
	SRR28919724_1.fastq.gz	Fastqsanger.gz
	SRR28919724_2.fastq.gz	Fastqsanger.gz
	SRR28919725_1.fastq.gz	Fastqsanger.gz

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Transgenerational inheritance of diabetes susceptibility in male offspring with maternal hyperandrogenism [WGBS]

Project description:Maternal hyperandrogenism is closely related to metabolic disorders, yet its transgenerational effects on male descendants remain unclear. Here we demonstrate that hyperandrogenism in women predisposes their sons to islet β-cell dysfunction. Male offspring mice with prenatal androgen exposure exhibited hyperglycemia and glucose intolerance due to compromised insulin secretion. Notably, these metabolic disturbances were transmitted across three generations, and exacerbated by aging and a high-fat diet. Altered DNA methylations in F1 sperm and F2 islet contribute to suppressed β-cell functional genes. We identified shared differentially methylated signatures in F1 sperm, type 2 diabetes patients, and sons with maternal hyperandrogenism. Furthermore, caloric restriction and metformin treatments in F1 males corrected hyperglycemic defects and prevented their transmission to offspring. Our findings highlight the transgenerational inheritance of hyperglycemia and β-cell dysfunction in male offspring from maternal hyperandrogenism via DNA methylation changes, providing methylation biomarkers and therapeutic strategies to safeguard future generations’ metabolic health.

2025-02-19 | GSE266699 | GEO

Transgenerational inheritance of diabetes susceptibility in male offspring with maternal hyperandrogenism [RNA-Seq]

2025-02-19 | GSE266255 | GEO

Transgenerational inheritance of diabetes susceptibility in male offspring with maternal hyperandrogenism

Project description:Transgenerational inheritance of diabetes susceptibility in male offspring with maternal hyperandrogenism

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Transgenerational inheritance of diabetes susceptibility in male offspring with maternal hyperandrogenism [RNA-Seq]

Project description:Transgenerational inheritance of diabetes susceptibility in male offspring with maternal hyperandrogenism [RNA-Seq]

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Transgenerational inheritance of diabetes susceptibility in male offspring with maternal hyperandrogenism

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-02-19 | GSE267720 | GEO

The chromatin modifiers SET-25 and SET-32 are required for initiation but not long-term maintenance of transgenerational epigenetic inheritance

Project description:Some epigenetic modifications are inherited from one generation to the next, providing a potential mechanism for the inheritance of environmentally acquired traits. Transgenerational inheritance of RNA interference phenotypes in C. elegans provides an excellent model to study this phenomenon, and whilst studies have implicated both chromatin modifications and small RNA pathways in heritable silencing their relative contributions remain unclear. Here we demonstrate that the histone methyltransferases SET-25 and SET-32 are required for the establishment of a transgenerational silencing signal, but not for long-term maintenance of this signal between subsequent generations suggesting that transgenerational epigenetic inheritance is a multi-step process, with distinct genetic requirements for establishment and maintenance of heritable silencing. Furthermore, small RNA sequencing reveals that the abundance of secondary siRNA (thought to be the effector molecules of heritable silencing) does not correlate with silencing phenotypes. Together, our results suggest that the current mechanistic models of epigenetic inheritance are incomplete.

2018-10-30 | PXD008754 | Pride

Transcriptome analysis in transgenerational epigenetic inheritance

Project description:Transcriptome analysis in transgenerational epigenetic inheritance

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Chromatin epimutations in transgenerational epigenetic inheritance

Project description:Chromatin epimutations in transgenerational epigenetic inheritance

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Stress Resets Transgenerational Small RNA Inheritance

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Stress Resets Transgenerational Small RNA Inheritance

Project description:Transgenerational inheritance is challenging basic concepts of heredity and achieving control over such responses is of great interest. In C. elegans nematodes, small RNAs are transmitted across generations to establish a transgenerational memory trace of ancestral environments. Inheritance of small RNAs is regulated by dedicated machinery and can be tuned by outside cues. Carryover of aberrant heritable small RNA responses was shown to be maladaptive and to induce sterility in certain cases. Here we show that various types of stress (starvation, high temperatures, and hyperosmotic conditions) but not non-stressful changes in cultivation, lead to resetting of small RNA inheritance. We found that stress leads to a genome-wide reduction in heritable small RNA levels and that mutants defective in different stress pathways exhibit irregular RNAi inheritance dynamics. Moreover, we discovered that resetting of heritable RNAi is orchestrated by MAPK pathway factors, the transcription factor SKN-1, and the MET-2 methyltransferase. Termination of small RNA inheritance, and the fact that this process depends on stress, could protect from run-on of environment-irrelevant heritable gene regulation.

2021-03-24 | GSE129988 | GEO

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