Ontology highlight
ABSTRACT:
PROVIDER: PRJNA110957 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:We sequenced mRNA from E18.5 mouse cortex (3 wild-type vs 3 Nova2-/- and 3 wild-type vs 3 Nova1-/-) and from E18.5 mouse mid- and hind-brain (3 wild-type vs 3 Nova1-/-) to compare gene expression level and alternative splicing events between wild-type and Nova mutant mice.
2016-05-26 | GSE69709 | GEO
Project description:RNA-Seq analysis of E18.5 mouse Zfp800 knockout vs wild-type
2021-01-15 | E-MTAB-9538 | ExpressionAtlas
Project description:Wild type vs. Ptbp2 KO mouse embryonic cortex RNA
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Project description:Wild type vs. Nova2 KO mouse: Exon junction array data
| PRJNA119109 | ENA
Project description:To assess the requirement of Nova2 for alternative processing of RNA in mouse brain. Protein-RNA interactions play critical roles in all aspects of gene expression. Here we develop a genome-wide means of mapping protein-RNA binding sites in vivo, by high throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP). HITS-CLIP analysis of the neuron-specific splicing factor Nova2 revealed extremely reproducible RNA binding maps in multiple mouse brains. These maps provide genome-wide in vivo biochemical footprints confirming the previous prediction that the position of Nova binding determines the outcome of alternative splicing; moreover, they are sufficiently powerful to predict Nova action de novo. HITS-CLIP revealed a large number of Nova-RNA interactions in 3â UTRs, leading to the discovery that Nova regulates alternative polyadenylation in the brain. HITS-CLIP, therefore, provides a robust, unbiased means to identify functional protein-RNA interactions in vivo. Keywords: Comparative analysis Refer to individual Series. This SuperSeries is composed of the following subset Series: GSE17374: Wild type vs. Nova2 KO mouse: Exon array data GSE17376: Wild type vs. Nova2 KO mouse: Exon junction array data
2010-06-20 | E-GEOD-12965 | biostudies-arrayexpress
Project description:Mouse cortex samples from E18.5 wild-type were subjected to HITS-CLIP to detect NOVA2 and NOVA1 binding positions on RNA
2016-05-26 | GSE69710 | GEO
Project description:Mouse CD4+/CD8+ thymocytes from miR-181a1/b1 KO vs WT
2019-05-14 | E-GEOD-41090 | ExpressionAtlas