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Transcriptional changes in A549 cells after four weeks of exposure to 30 μg/ml diesel exhaust particles measured by RNA-seq.

ABSTRACT: Transcriptional changes in A549 cells after four weeks of exposure to 30 μg/ml diesel exhaust particles measured by RNA-seq.

PROVIDER: PRJNA1110256 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28995929_1.fastq.gz	Fastqsanger.gz
	SRR28995929_2.fastq.gz	Fastqsanger.gz
	SRR28995930_1.fastq.gz	Fastqsanger.gz
	SRR28995930_2.fastq.gz	Fastqsanger.gz
	SRR28995931_1.fastq.gz	Fastqsanger.gz

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Transcriptional changes in A549 cells after four weeks of exposure to 30 μg/ml diesel exhaust particles measured by RNA-seq.

Project description:Diesel exhaust particles (DEP), which contain hazardous compounds, are emitted during the combustion of diesel. As approximately one-third of the vehicles worldwide use diesel, there are growing concerns on the risks posed by DEP to human health. Long-term exposure to DEP is associated with airway hyperresponsiveness, pulmonary fibrosis, and inflammation; however, the molecular mechanisms behind the effects of DEP on the respiratory tract are poorly understood. Such mechanisms can be addressed by examining transcriptional and DNA methylation changes. In this study, we investigated the effect of 4 weeks exposure to 30 μg/ml DEP on gene expression levels in A549 cells.

2024-08-05 | GSE267213 | GEO

DNA methylation changes in A549 cells after four weeks of exposure to 30 μg/ml diesel exhaust particles.

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Transcriptional changes in A549 cells after four weeks of exposure to 30 μg/ml diesel exhaust particles measured by Agilent SurePrint G3 Human Gene Expression Microarray.

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Lung cell responses to ship diesel exhaust particles

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Diesel exhaust particles Enhance Monocyte Recruitment, Accelerating Allergic Airway Inflammation

Project description:We performed single-cell RNA sequencing on CD45+ cells isolated from the lungs of C57BL/6 mice exposed to diesel exhaust particles via inhalation. The objective was to investigate which immune cells respond to particulate matter exposure.

2025-03-24 | GSE283909 | GEO

Effect of Diesel Exhaust Particles in Normal Human Embryonic Lung Cell (WI-38) Line

Project description:We performed RNA sequencing to identify genes and pathways induced by Diesel exhaust particles exposure in WI-38 cells.

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DNA methylation changes in A549 cells after four weeks of exposure to 30 μg/ml diesel exhaust particles.

Project description:DNA methylation changes in A549 cells after four weeks of exposure to 30 μg/ml diesel exhaust particles.

| PRJNA1110258 | ENA

Transcriptional changes in A549 cells after four weeks of exposure to 30 μg/ml diesel exhaust particles measured by Agilent SurePrint G3 Human Gene Expression Microarray.

Project description:Transcriptional changes in A549 cells after four weeks of exposure to 30 μg/ml diesel exhaust particles measured by Agilent SurePrint G3 Human Gene Expression Microarray.

| PRJNA1110257 | ENA

Murine lung: Control vs Diesel Exhaust Exposed

Project description:MicroRNA microarray profiling of Murine lung exposed to diesel exhaust

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Lung cell responses to ship diesel exhaust particles

Project description:Human BEAS-2B bronchial epithelial cells were exposed directly at the air-liquid interphase towards exhaust gas and particles of a ship engine. The goal was to compare the responses towards different fuel combustions. The engine run either on diesel fuel (DF) or on Heavy Fuel Oil (HFO). The lung cells were exposed 3 times to each combustion aerosol (DF or HFO). The duration of the exposure was 4h. The cells were seeded into transwell-inserts 24h before exposure. Within each exposure 3 transwell-inserts were exposed to the complete aerosol and 3 transwell-inserts were exposed to the filtered aerosol. Effects of the complete aerosol were referenced against the filtered aerosol to determine the effects of the aerosol particles.

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