Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MSA: Scalable DNA methylation BeadChip for human trait screening [EM-seq]

ABSTRACT: MSA: Scalable DNA methylation BeadChip for human trait screening [EM-seq]

PROVIDER: PRJNA1111447 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR29020037_1.fastq.gz	Fastqsanger.gz
	SRR29020037_2.fastq.gz	Fastqsanger.gz
	SRR29020038_1.fastq.gz	Fastqsanger.gz
	SRR29020038_2.fastq.gz	Fastqsanger.gz
	SRR29020039_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

MSA: Scalable DNA methylation BeadChip for human trait screening

Project description:MSA: Scalable DNA methylation BeadChip for human trait screening

| PRJNA1102411 | ENA

MSA: Scalable DNA methylation BeadChip for human trait screening [EM-seq]

Project description:We designed and introduced a new methylation array concentrating on human trait screening and discovery. The new MSA (Methylation Screening Array) leveraged the massive Infinium platform-based data from epigenome-wide association studies, combined with updated knowledge from the latest single cell and cell type-resolution whole genome methylome profiles, to achieve scalable screening of epigenetics-trait association in an ultra-high sample-throughput. Our design encompassed diverse human trait associations, including those with genetic, biological, and demographical variables, environmental exposures, and common human diseases such as neurodegenerative, genetic, cardiovascular, infectious, and immune diseases. We comprehensively evaluated this array's reproducibility, accuracy, and capacity in supporting 5-hydroxymethylation profiling and comprehensive cell-type deconvolution in diverse human tissues. Our first data using this platform uncovered dynamic chromatin and tissue contexts of DNA modification variations and genetic variants with human trait associations.

2024-05-18 | GSE267407 | GEO

MSA: Scalable DNA methylation BeadChip for human trait screening

2024-05-11 | GSE264438 | GEO

Epigenome-Wide Association Study in multiple system atrophy (MSA)

Project description:Genome-wide methylation profiling of DNA extracted from the prefrontal cortex of post-mortem MSA patients (n=41) or normal, healthy controls (CTRLs; n=37). The Illumina Infinium MethylationEPIC BeadChip was used, investigating app. 850,000 CpG sites throughout the genome

2020-03-10 | GSE143157 | GEO

Mosaic MSA

Project description:Mosaic MSA

| PRJEB37002 | ENA

Differentially methylated genes in human IL-7Ra high and low EM CD8+ T cells

Project description:Genome wide DNA methylation profiling of IL-7Ra high and low EM CD8+ T cells. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,578 CpGs. Samples included 2 IL-7Ra high EM CD8+ T cells and 2 IL-7Ra high EM CD8+ T cells. Bisulphite converted DNA from the 4 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2

2015-08-06 | E-GEOD-67816 | biostudies-arrayexpress

Differentially methylated genes in human IL-7Ra high and low EM CD8+ T cells

2015-08-06 | GSE67816 | GEO

Phosphoproteomic analysis of IL-2 MSA and IL-12 MSA combination on T cell signaling

Project description:Engineered cytokine-based approaches for immunotherapy of cancer are poised to enter the clinic, with IL-12 being at the forefront. However, little is known about potential mechanisms of resistance to cytokine therapies. We found that orthotopic murine lung tumors were resistant to systemically delivered IL-12 fused to murine serum albumin (MSA, IL12-MSA) due to low IL-12R expression on tumor-reactive CD8+ T cells. IL2-MSA increased binding of IL12-MSA by tumor-reactive CD8+ T cells, and combined administration of IL12-MSA and IL2-MSA led to enhanced tumor-reactive CD8+ T cell effector differentiation, decreased numbers of tumor-infiltrating CD4+ regulatory T (Treg) cells, and increased survival of lung tumor-bearing mice. Predictably, the combination of IL-2 and IL-12 at therapeutic doses led to significant dose-limiting toxicity. Administering IL-12 and IL-2 analogs with preferential binding to cells expressing IL12rb1 and CD25, respectively, led to a significant extension of survival in mice with lung tumors while abrogating dose-limiting toxicity. These findings suggest that IL-12 and IL-2 represent a rational approach to combination cytokine therapy whose dose-limiting toxicity can be overcome with engineered cytokine variants.

2024-01-26 | PXD044740 | Pride

Iron-related gene expression in MSA

Project description:Human post-portem Multiple System Atrophy (MSA) and control aged brains were examined for mRNA expression of iron-related genes

2024-08-17 | GSE241198 | GEO

MSA brain sequencing

Project description:Sequencing of DNA from MSA brain

| PRJEB35076 | ENA