Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic changes associated to the exposure of intestinal cells to the mycotoxin Versicolorin A

ABSTRACT: Transcriptomic changes associated to the exposure of intestinal cells to the mycotoxin Versicolorin A

PROVIDER: PRJNA1111875 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Transcriptomic changes associated to the exposure of intestinal cells to the mycotoxin Versicolorin A

Project description:Versicolorin A (VerA), a precursor of the potent carcinogen aflatoxin B1 (AFB1), is an emerging mycotoxin. Recent studies have described the mutagenic and genotoxic ability of VerA, but the mechanisms of its toxicity remain to be discovered. In the present study, we investigated the early (6 h) transcriptomic changes induced by VerA in differentiated intestinal cells at non-cytotoxic conditions (1 and 3 µM) and compared its effects to those of AFB1 at 1µM. Our results showed that VerA, but not AFB1, induced significant changes in global gene expression profiles. Both toxins induced gene expression changes related to known elements of their toxicity, such as mutagenicity, genotoxicity, oxidative stress and apoptosis. However, we also observed novel features of VerA toxicity, including the ability to induce mitochondrial dysfunction, which leads to the induction of a type-1 interferon response mediated by cGAS-STING. VerA also induced changes in the expression of genes involved in the regulation of cell shape and adhesion, transcription/translation as well as genes associated with tumor biology. Our findings provide new evidence of VerA toxicity and highlight the need to further evaluate its hazards and the risk associated with its presence in food.

2025-05-31 | GSE267572 | GEO

Mycotoxin exposure is associated with infant gut microbiome composition

Project description:Mycotoxin exposure is associated with infant gut microbiome composition Raw sequence reads

| PRJNA1013123 | ENA

Transcriptomic Changes in the Nasal Epithelium Associated with Diesel Engine Exhaust Exposure

Project description:Diesel engine exhaust (DEE) is one of the major contributors to air pollution around the world, and exposure to DEE is associated with lung cancer and other airway diseases. Although recent studies have investigated the effects of exposure to DEE, the mechanisms by which it leads to lung cancer pathogenesis are not well understood. We have previously investigated the transcriptomic changes that occur due to exposure to cigarette smoke and burning of bituminous (smoky) as well as anthracite (smokeless) coal in the airway epithelium, and in this study we assess the gene expression alterations in the nasal epithelium that are associated with chronic DEE exposure of diesel engine factory workers to better understand which molecular changes may lead to pathogenesis of lung cancer.

2019-12-19 | GSE124267 | GEO

Transcriptomic changes associated with specific Dhps deletion in intestinal epithelial cells

Project description:Transcriptomic changes associated with specific Dhps deletion in intestinal epithelial cells

| PRJNA832230 | ENA

Transcriptomic Changes in the Nasal Epithelium Associated with Diesel Engine Exhaust Exposure

Project description:Transcriptomic Changes in the Nasal Epithelium Associated with Diesel Engine Exhaust Exposure

| PRJNA511440 | ENA

ChIP-seq genome-wide maps of nuclear receptor RORγ chromatin state in the liver of pig exposed to mycotoxin

Project description:We show that RORγ functions as a master activator of the entire mevalonate pathway-cholesterol biosynthesis program in the porcine liver. RORγ genome-wide binding enrichments in the liver were significantly reduced in response to mycotoxin exposure.

2024-02-01 | GSE166520 | GEO

RNAseq data for chicken liver cells under mycotoxin treatment

Project description:RNAseq data for chicken liver cells under mycotoxin treatment

2019-06-21 | GSE112862 | GEO

Transcriptomic Changes in Human Pulmonary Fibroblasts Following Microplastics Exposure

Project description:Transcriptomic Changes in Human Pulmonary Fibroblasts Following Microplastics Exposure

| PRJNA1257307 | ENA

Transcriptomic Changes in Mouse Trophoblast Cells Following Oxycodone Exposure

Project description:Transcriptomic Changes in Mouse Trophoblast Cells Following Oxycodone Exposure

| PRJNA909296 | ENA

Seasonal changes in intestinal viruses

Project description:Seasonal changes in intestinal viruses