Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Insulin-like growth factor 2 (IGF2) as a Foxn1-independent driving force of exponential expansion in neonatal thymus

ABSTRACT: Insulin-like growth factor 2 (IGF2) as a Foxn1-independent driving force of exponential expansion in neonatal thymus

PROVIDER: PRJNA1112436 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR29060500_1.fastq.gz	Fastqsanger.gz
	SRR29060500_2.fastq.gz	Fastqsanger.gz
	SRR29060501_1.fastq.gz	Fastqsanger.gz
	SRR29060501_2.fastq.gz	Fastqsanger.gz
	SRR29060502_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 200

Similar Datasets

Insulin-like growth factor 2 (IGF2) as a Foxn1-independent driving force of exponential expansion in neonatal thymus

Project description:Like all organs, the thymus grows in size and function rapidly during development, which comes to a halt after birth. However, the molecular mechanisms behind such a transition in the thymus remain obscure. Using single-cell RNA sequencing (scRNA-seq) of the murine thymic stroma, we identified that major transcriptomic changes occur in the endothelium and mesenchyme across the transition to homeostasis. Differentially expressed gene and intercellular network analyses of temporally resolved scRNA-seq data revealed fibroblast-derived insulin-like growth factor 2 (IGF2) as a candidate driving neonatal thymic expansion. We demonstrated IGF2 activity promotes a cortical TEC-specific proliferation and is tightly regulated at the thymic growth transition. Bulk RNA-seq of human thymi across the transition also revealed IGF2 to drive thymic expansion, suggesting an evolutionarily conserved role. Our study highlights the role of a fibroblast-derived IGF2 in promoting cTEC proliferation, resulting in early thymic expansion that is followed by down-regulation to establish homeostasis.

2025-03-19 | GSE267706 | GEO

Insulin-like growth factor 2 (IGF2) as a driving force of exponential expansion in neonatal thymus

Project description:Insulin-like growth factor 2 (IGF2) as a driving force of exponential expansion in neonatal thymus

| PRJNA1112875 | ENA

Insulin-like growth factor 2 (IGF2) as a driving force of exponential expansion in neonatal thymus

2025-03-20 | GSE267785 | GEO

Transcriptional profile by mRNA microarrays of cervical thymus, thoracic thymus and parathyroid from Foxn1-GFP; Pth-Cre; R26dTomato transgenic mice

Project description:Whole mouse genome microarrays from Agilent were used to determine expression profile of whole organ cervical thymus, thoracic thymus and parathyroid from Foxn1-GFP; Pth-Cre; R26dTomato transgenic mice.

2015-07-31 | E-MTAB-3751 | biostudies-arrayexpress

Transcriptional regulation of the thymus master regulator Foxn1

Project description:Transcriptional regulation of the thymus master regulator Foxn1

| PRJNA793576 | ENA

Transcriptional regulation of the thymus master regulator Foxn1 [RNAseq_dev_HFC]

Project description:Transcriptional regulation of the thymus master regulator Foxn1 [RNAseq_dev_HFC]

| PRJNA793580 | ENA

Transcriptional regulation of the thymus master regulator Foxn1 [WGBS]

Project description:Transcriptional regulation of the thymus master regulator Foxn1 [WGBS]

| PRJNA816079 | ENA

Transcriptional regulation of the thymus master regulator Foxn1 [RNAseq_AR3_vs_nude]

Project description:Transcriptional regulation of the thymus master regulator Foxn1 [RNAseq_AR3_vs_nude]

| PRJNA793578 | ENA

Transcriptional regulation of the thymus master regulator Foxn1 [WGBS]

Project description:FOXN1 is a transcription factor critical for the development of both thymic epithelial cell (TEC) and hair follicle cell (HFC) compartments. However, mechanisms controlling its expression remain poorly understood. To address this question, we performed thorough analyses of the conservation and chromatin status of the Foxn1 locus in different tissues and states, and identified several putative cis-regulatory regions unique to TEC vs. HFC. Furthermore, experiments using genetically modified mice with specific deletions in the Foxn1 locus and additional bioinformatic analyses helped us identify key regions and transcription factors involved in either positive or negative regulation of Foxn1 in both TEC and HFC. Specifically, we identified SIX1 and FOXN1 itself, as key factors inducing Foxn1 expression in embryonic and neonatal TECs. Together, our data provide important mechanistic insights into the transcriptional regulation of the Foxn1 gene in TEC vs. HFC and highlight the role of FOXN1 in its autoregulation

2022-08-03 | GSE198591 | GEO

Transcriptional regulation of the thymus master regulator Foxn1 [RNAseq_AR3_vs_nude]

2022-08-03 | GSE192872 | GEO