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Myrothamnus flabellifolia

ABSTRACT: Myrothamnus flabellifolia resequencing, genome assembly and annotation

PROVIDER: PRJNA1114756 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR29328200_1.fastq.gz	Fastqsanger.gz
	SRR29328200_2.fastq.gz	Fastqsanger.gz
	SRR29328300_1.fastq.gz	Fastqsanger.gz
	SRR29328300_2.fastq.gz	Fastqsanger.gz

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1 - 5 of 338

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Polyphenols from Myrothamnus flabellifolia Welw. inhibit in vitro adhesion of Porphyromonas gingivalis and exert anti-inflammatory cytoprotective effects in KB cells

Project description:Investigation of whole genome gene expression level changes in Porphyromonas gingivalis ATCC 33277 treated with an anti-adhesive extract from Myrothamnus flabellifolia compared to the untreated strain. Aim: Identification of anti-adhesive plant extracts against cell surface binding of Porphyromonas gingivalis. Materials and Methods: Polyphenol-enriched extract from Myrothamnus flabellifolia (MF) traditionally used for periodontitis was tested for inhibition of P. gingivalis adhesion to KB cells by FACS, for influence on gingipain activity, hemagglutination and by microarray analysis for effects on the bacterial transcriptome. P. gingivalis-induced inflammation parameters were monitored by RT-PCR. Results: MF (100 µg/ml) reduced P. gingivalis adhesion/invasion about 50% by interacting with fimbriae and bacterial OMPs. Microarray analysis of MF-treated bacteria indicated up-regulation of genes involved in cell adhesion. As confirmed by RT-PCR, fimbrillin- and Arg-gingipain-encoding genes were upregulated by MF. On the protein level, inhibition (70%) of Arg-gingipain activity was observed, while the corresponding Lys-gingipain was hardly influenced. MF also inhibited hemagglutination. While exposure to P. gingivalis resulted in an increased expression of inflammation-related genes in KB cells, pretreatment of KB cells with MF evoked cytoprotective effects concerning IL-1β, IL-6, IL-8 and TNFα gene expression as well as IL-6 release rates. Conclusions: While being cytoprotective, MF exerts strong anti-adhesive effects against P. gingivalis. Thus, MF may be useful for the prevention of P. gingivalis-associated periodontal diseases.

2010-09-02 | GSE23939 | GEO

Myrothamnus flabellifolia cultivar:BK_DT_4

Project description:Myrothamnus flabellifolia BK_DT_4 Resequencing genome sequencing

| PRJNA1114148 | ENA

Myrothamnus flabellifolius

Project description:Myrothamnus flabellifolia overview

| PRJNA1114363 | ENA

Polyphenols from Myrothamnus flabellifolia Welw. inhibit in vitro adhesion of Porphyromonas gingivalis and exert anti-inflammatory cytoprotective effects in KB cells

2010-09-02 | E-GEOD-23939 | biostudies-arrayexpress

Myrothamnus flabellifolius cultivar:SSDT_37

Project description:Myrothamnus flabellifolia SSDT_37 Standard Draft genome sequencing

| PRJNA1114142 | ENA

Myrothamnus flabellifolius cultivar:SSDT_33

Project description:Myrothamnus flabellifolia SSDT_33 Gene Expression Profiling - SSDT_33 Dh4 transcriptome

| PRJNA1114154 | ENA

Myrothamnus flabellifolius cultivar:SSDT_33

Project description:Myrothamnus flabellifolia SSDT_33 Gene Expression Profiling - SSDT_33 Dh5 transcriptome

| PRJNA1114155 | ENA

Myrothamnus flabellifolius cultivar:SSDT_36

Project description:Myrothamnus flabellifolia SSDT_36 Gene Expression Profiling - SSDT_36 Dh5 transcriptome

| PRJNA1114168 | ENA

Myrothamnus flabellifolius cultivar:SSDT_36

Project description:Myrothamnus flabellifolia SSDT_36 Gene Expression Profiling - SSDT_36 Dh6 transcriptome

| PRJNA1114169 | ENA

Myrothamnus flabellifolius cultivar:SSDT_37

Project description:Myrothamnus flabellifolia SSDT_37 Gene Expression Profiling - SSDT_37 Dh2 transcriptome

| PRJNA1114179 | ENA

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