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THP-1 derived macrophage samples with phagocytosis and non-phagocytosis of tumor cells

ABSTRACT: THP-1 derived macrophage samples with phagocytosis and non-phagocytosis of tumor cells

PROVIDER: PRJNA1117360 | ENA |

REPOSITORIES: ENA

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THP-1 derived macrophage samples with phagocytosis and non-phagocytosis of tumor cells

Project description:THP-1 derived macrophage samples with phagocytosis and non-phagocytosis of tumor cells (duplicates for each condition).

2025-07-15 | GSE268430 | GEO

ozone-derived oxisterols impair lung macrophage phagocytosis via adduction of phagocytosis receptors

Project description:Inhalation of the amibient air polution ozone causes lung inflammation and can suppress host defense mechanisms, including impairing macrophage phagocytosis. Ozone reacts with cholesterol in the lung to form oxysterols, like secosterol A and secosterol B, which can form covalent adducts on cellular proteins. How oxysterol-protein adduction modifies the function of lung macrophages is unknown. Herein, we used a preoteomic screen to identify lung macrophage proteins that fomr adducts with ozone-derived oxysterols. Analysis show that the phagocytic receptor CD206 and CD64 formed adducts with secosterol A. Adduction of these receptors with ozone-derived oxysterols impaired ligand binding and corresponded with reduced macrophage phagocytosis. This work suggests a novle mechanism for the suppression of macrophage phagocytosis following ozone exposure through the generation of oxysterols and the formation of oxysterol-protein adducts on phagocytic receptors.

2020-07-18 | PXD019317 | Pride

Comparison of a macrophage like cell line derived from THP-1 cells

Project description:There is currently no human macrophage cell line and in vitro experiments requiring these cells currently require mitogenic stimulation of a macrophage precursor cell line (for example THP-1 cells) or ex vivo maturation of circulating primary monocytes. We have derived a unique sub-clone of the THP-1 cell line capable of spontaneous and perpetual differentiation into alveolar macrophage-like cells. Here we used the Agilent G4851C (v3) array to look at the gene expression of the new cell line which can be compared it with THP-1 cells and PMA stimulate THP-1 cells (Accession number E-MTAB-4153). In addition the new human alveolar macrophage like cell line has been treated with unmodified lipid to look at lipid uptake by these cells and the effect on gene expression.

2020-01-31 | E-MTAB-7169 | biostudies-arrayexpress

Foxp3 promotes macrophage phagocytosis in AIS

Project description:Foxp3 promotes macrophage phagocytosis in AIS

| PRJNA852849 | ENA

LncRNA/mRNA expression profiling for THP-1 macrophages and THP-1 macrophage-derived foam cells

Project description:By identifying differentially expressed LncRNAs/mRNAs in THP-1 macrophages and THP-1 macrophage-derived foam cells, we select some differentially expressed LncRNAs and explore their roles in atherosclerosis process. We already find that some LncRNA can effect cholesterol metabolism and level of inflammation factor, which may influence atherosclerosis process. In the study presented here, 6 human samples were used to acquire expression profiles, which provide futher insight into the pathologies of atherosclerosis

2014-05-20 | E-GEOD-54039 | biostudies-arrayexpress

LncRNA/mRNA expression profiling for THP-1 macrophages and THP-1 macrophage-derived foam cells

2014-05-20 | GSE54039 | GEO

Response of M. guilliermondii to macrophage phagocytosis

Project description:Response of M. guilliermondii to macrophage phagocytosis

| PRJNA636086 | ENA

Global transcriptional profile of hESC-derived macrophage (iMAC), human monocyte-derived macrophage and THP-1 macrophage

Project description:Global transcriptional profile of hESC-derived macrophage (iMAC), human monocyte-derived macrophage and THP-1 macrophage

| PRJNA575728 | ENA

Neutrophil Death Medicates Alveolar Macrophage Proliferation and Phagocytosis

Project description:Neutrophil Death Medicates Alveolar Macrophage Proliferation and Phagocytosis

| PRJNA873918 | ENA

EDL933 in human macrophage THP-1 cells at different time point

Project description:Effect of human macrophages phagocytosis on the global transcriptome of EDL933 at different time. Infection of THP-1 with EDL933. Application of SCOTS technique to have cDNA. Hybridation on microarray. Reference: EDL933 in RPMI medium Keywords: stres response, host-bacteria response, time-course For each time point, 2 microarray are analysed and on each microarray there is 2 replicate Total of 4 replicate for each time point (including reference medium)

2010-06-24 | E-GEOD-9671 | biostudies-arrayexpress

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