RELMα establishes a permissive environment for influenza infection through direct effects on lung epithelial cells
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1118671 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR29245001_1.fastq.gz | Fastqsanger.gz | |||
| SRR29245001_2.fastq.gz | Fastqsanger.gz | |||
| SRR29245002_1.fastq.gz | Fastqsanger.gz | |||
| SRR29245002_2.fastq.gz | Fastqsanger.gz | |||
| SRR29245003_1.fastq.gz | Fastqsanger.gz |
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Project description:The RELMα+ macrophage phenotype associates with the presence of anti-inflammatory macrophages and work in other model systems has demonstrated that the balance of pro-inflammatory and anti-inflammatory macrophages is critically important in enabling the resolution of inflammation. Moreover, in the context of type 2 immunity, RELMα+ anti-inflammatory macrophages are associated with the activation of macrophages via the IL4Ra. Despite a breadth of inflammatory pathologies associated with the large intestine, including those that accompany parasitic infection, it is not known about how large intestinal macrophages are activated towards an anti-inflammatory phenotype.
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