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Homo sapiens

ABSTRACT: Antileukemic activity of valproic acid in chronic lymphocytic leukemia cells defined by microarray analysis

OTHER RELATED OMICS DATASETS IN: E-GEOD-14973

PROVIDER: PRJNA111871 | ENA |

REPOSITORIES: ENA

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Antileukemic activity of valproic acid in chronic lymphocytic leukemia cells defined by microarray analysis

Project description:Epigenetic code modifications by histone deacetylase inhibitors (HDACi) have recently been proposed as potential new therapies for hematological malignancies. Chronic Lymphocytic Leukemia (CLL) remains incurable despite the introduction of new treatments. CLL cells are characterized by an apoptosis defect rather than excessive proliferation, but proliferation centers have been found in organs such as bone marrow and lymph nodes. Here, we investigated gene expression modifications in CLL cells following treatment with valproic acid (VPA), a well-tolerated anti-epileptic drug with HDAC inhibitory activity.

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Nanda2013 - B cell chronic lymphocytic leukemia A model with immune response

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Project description:Transcription profiling by array of human chronic lymphocytic leukemia cells after treatment with valproic acid

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