Project description:The antitumor drug daunorubicin exerts some of its cytotoxic effects by binding to DNA and inhibiting the transcription of different genes. We analysed this effect in vivo transcriptome level using the budding yeast Saccharomyces cerevisiae as a model and sublethal concentrations of the drug to minimise general toxic effects. The effects of daunorubicin treatment on the yeast transcriptome are consistent with a model in which this drug impairs binding of different transcription factors by competing for their DNA binding sequences, therefore limiting their effectiveness and affecting the corresponding regulatory networks. This proposed mechanism might have broad therapeutic implications against cancer cells growing under hypoxic conditions. Keywords: Time course experiment (treated versus non-treated)

2009-12-08 | GSE19351 | GEO

Selective inhibition of yeast regulons by daunorubicin

2010-05-18 | E-GEOD-19351 | biostudies-arrayexpress

RNA-Seq analysis of HL-60 AML cells resistant to daunorubicin or cytarabine

Project description:The Acute Myeloid Leukemia cell line HL-60 was rendered resistant to daunorubicin (DNR) or cytarabine (Ara-C) by continuous exposure to the drug up to concentrations of 30nM for DNR and 100nM for Ara-C. Transcriptomic analysis were then performed by RNA-Seq to compare the cell lines

2022-01-08 | GSE193094 | GEO

Effect of SWI/SNF pertubations on macrophage inflammatory activation [RNA-seq]

Project description:Effect of SWI/SNF pertubations on macrophage inflammatory activation [RNA-seq]

| PRJNA1014767 | ENA

RNA-Seq analysis of HL-60 AML cells resistant to daunorubicin or cytarabine

Project description:RNA-Seq analysis of HL-60 AML cells resistant to daunorubicin or cytarabine

| PRJNA794751 | ENA

Antiphage capacity of Daunorubicin

Project description:Studying the daunorubicin-mediated inhibition of T5-like phage Bas33

| PRJEB101990 | ENA

RNA-sequencing analysis of the effect of progesterone on T cell activation

Project description:RNA-sequencing analysis of the effect of progesterone on T cell activation