Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Spirochetes isolated from mosquitoes constitute a novel genus Entomospira genus novum

PROVIDER: PRJNA1121616 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR29330639_1.fastq.gz	Fastqsanger.gz
	SRR29330640_1.fastq.gz	Fastqsanger.gz
	SRR29330641_1.fastq.gz	Fastqsanger.gz
	SRR29330642_1.fastq.gz	Fastqsanger.gz
	SRR29330643_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Entomospira genus nov

Project description:Spirochetes isolated from mosquitoes constitute a novel genus Entomospira genus novum within the order Spirochaetales

| PRJNA611537 | ENA

Project description:Spirochetes isolated from mosquitoes constitute a novel genus Entomospira genus novum within the order Spirochaetales

| PRJNA934383 | ENA

Multi-omics analysis of arboviral capsid targets in mosquitoes reveals a pro-viral function of the chromatin-remodeling Brahma complex

Project description:In recent years, arboviral infections have surged dramatically due to the geographic expansion of Aedes and Culex mosquitoes, their main vector mosquitoes. Despite significant efforts to uncover arbovirus–host interactions and viral protein effector functions in mammals, systematic studies aiming to characterize virus–vector interactions in arthropods are largely missing, and the functions and cellular targets of many arboviral proteins in mosquitoes remain elusive. Here, we applied a multi-omic approach to systematically evaluate the ability of arboviral capsids to interact with the Ae. aegypti proteome. This extensive multi-modal atlas across 12 pathogenic arboviral species spanning three viral genera revealed shared and distinct host factor specificities, uncovering species-, genus- and vector preference-specific patterns of host usage in mosquitoes. Functional phenotypic screening of 110 newly discovered host proteins across three prototypic arboviruses (La Crosse virus, dengue virus and West Nile virus) identified several novel host dependency factors, including a new role for the chromatin-remodeling Brahma complex in orthoflavivirus replication. Using a combination of biochemical and sequencing approaches, we characterized the cellular determinants of these interactions and profiled their functional consequences on the chromatin landscape. Altogether, this study provides a multi-layered repository to categorize and characterize arboviral capsid effector functions in invertebrates, providing important cues on novel mechanisms of transcriptional regulation via capsid-mediated modulation of chromatin accessibility in insects.

2026-02-05 | PXD070116 | Pride

Epigenomic landscape of Lyme disease spirochetes reveals novel motifs

Project description:Epigenomic landscape of Lyme disease spirochetes reveals novel motifs

| PRJNA716641 | ENA

Project description:Anaerococcus spp. novum

| PRJNA851429 | ENA

Mouse skin samples after Zika virus-infected mosquito bites

Project description:Mouse skin bitten by Zika virus-infected mosquitoes were isolated and performed RNA-seq

2019-03-10 | GSE125194 | GEO

Neocallimastigomycota

Project description:Three novel genus-level lineages of Neocallimastigomycota isolated from tortoise feces

| PRJNA1345044 | ENA

Infectious EVs govern flavivirus infection in mosquitoes

Project description:The EVs isolated from haemolymph of DENV2-infected Ae. aegypti mosquitoes were identified by mass spectrometry.

| PXD069690 |

Host complement C3 promotes malaria transmission by killing symbiotic bacteria in the mosquito midgut

Project description:Host-derived factors are sucked into midgut of mosquitoes during natural malaria transmission, but their influence on malaria transmission is largely unknown. We reported that mouse complement C3 taken into mosquitoes significantly promoted malaria transmission either in laboratory or in field. This effect was attributed to the reduction of microbiota abundance in mosquito midgut by host-derived C3 through direct lyses the predominant symbiont bacteria Elizabethkingia anopheles. Elizabethkingia anopheles symbiont bacteria were demonstrated to be detrimental to malaria sexual stages in mosquitoes. Strikingly, the promoted effect of host C3 on malaria transmission was confirmed by laboratory mosquitoes membrane-feeding on Plasmodium falciparum. Therefore, we reveal a novel strategy of malaria parasite to utilize host complement C3 to promote its transmission, and the administration of C3 inhibitor would provide us a novel strategy to control malaria transmission.

2024-08-01 | GSE271070 | GEO

Sex-specific transcriptomic response of Anopheles gambiae to O'nyong Nyong virus infection

Project description:O’nyong’nyong virus (ONNV) is an arbovirus of the genus Alphavirus which is transmitted to humans primarily by mosquitoes of the genus Anopheles. Here, An. stephensi males and females have been infected with ONNV to investigate their differential transcriptional response to infection. Males and female An. gambiae were injected with either a suspension of ONNV or sterile medium as a control and underwent pooled RNA extraction at 2- and 7-days post infection (DPI). Differential expression will be performed on pooled RNA samples to determine which genes are differentially regulated between males and females in response to infection, and which genes are activated or repressed in each sex as infection progresses. Further, genes identified as being regulated by infection or that differ in expression between males and females will be used to perform gene ontology (GO) analysis to determine what pre-identified gene sets are regulated under the scenarios being examined.

2024-12-31 | GSE175395 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data