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The integrated stress response fine-tunes stem cell fate decisions in response to serine deprivation and tissue injury [RNA-seq]

ABSTRACT: The integrated stress response fine-tunes stem cell fate decisions in response to serine deprivation and tissue injury [RNA-seq]

PROVIDER: PRJNA1126199 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29482769.fastq.gz	Fastqsanger.gz
	SRR29482770.fastq.gz	Fastqsanger.gz
	SRR29482771.fastq.gz	Fastqsanger.gz
	SRR29482772.fastq.gz	Fastqsanger.gz
	SRR29482773.fastq.gz	Fastqsanger.gz

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The integrated stress response fine-tunes stem cell fate decisions in response to serine deprivation and tissue injury [scRNA-seq]

Project description:The integrated stress response fine-tunes stem cell fate decisions in response to serine deprivation and tissue injury [scRNA-seq]

| PRJNA1126186 | ENA

The integrated stress response fine-tunes stem cell fate decisions in response to serine deprivation and tissue injury [RNA-seq]

Project description:Epidermal stem cells constantly rejuvenate the skin’s barrier, which excludes harmful microbes and prevents dehydration. In routine wounds, underlying hair follicle stem cells (HFSCs), normally dedicated to hair regeneration, must also reconstruct and thereafter maintain the overlying epidermis. How these fate choices are balanced to restore physiologic function to damaged tissue remains poorly understood. Here, we uncover the non-essential amino acid serine as a surprising rheostat in this process. Utilizing diet and HFSC-specific loss-of-function studies, we show that under serine-depleted conditions, HFSCs delay hair growth, and upon injury skew their fate towards epidermal re-epithelialization while concomitantly limiting hair growth. Combining temporal single-cell RNA sequencing, genetics and pharmacological intervention, we show that serine deficiency augments an injury-activated integrated stress response (ISR), boosting re-epithelization and rapidly restoring the skin’s barrier at the wound edge. Our findings integrate injury, the ISR, metabolism, tissue fate-selection and repair, offering potential for dietary and pharmacologic intervention to accelerate wound healing.

2024-06-20 | GSE270324 | GEO

The integrated stress response fine-tunes stem cell fate decisions in response to serine deprivation and tissue injury [scRNA-seq]

2024-06-20 | GSE270317 | GEO

Gene Regulation by ATF3 in response to serine deprivation

Project description:The goal of this study is to identify genes that are regulated by activiating transcription factor (ATF3) in the cellular response to serine deprivation. Serine biosynthesis is crucial for cancer cells to proliferate and survival under serine-limiting conditions. We found that ATF3 expression induced by serine deprivation supports cancer cell growth. This RNA-seq study is thus designed to understand how ATF3 regulates serine biosynthesis in cells. The results indicate that ATF3 regulates the genes involved in the serine synthesis pathway.

2021-11-09 | GSE164850 | GEO

Gene Regulation by ATF3 in response to serine deprivation

Project description:Gene Regulation by ATF3 in response to serine deprivation

| PRJNA692204 | ENA

Smarca4 (Brg1) is a haploinsufficient B-cell tumor suppressor that fine-tunes centrocyte cell fate decisions

Project description:Smarca4 (Brg1) is a haploinsufficient B-cell tumor suppressor that fine-tunes centrocyte cell fate decisions

| PRJNA1072570 | ENA

Smarca4 (Brg1) is a haploinsufficient B-cell tumor suppressor that fine-tunes centrocyte cell fate decisions [pbrm1_atac]

Project description:Smarca4 (Brg1) is a haploinsufficient B-cell tumor suppressor that fine-tunes centrocyte cell fate decisions [pbrm1_atac]

| PRJNA1072577 | ENA

Smarca4 (Brg1) is a haploinsufficient B-cell tumor suppressor that fine-tunes centrocyte cell fate decisions [ca46_rna]

Project description:Smarca4 (Brg1) is a haploinsufficient B-cell tumor suppressor that fine-tunes centrocyte cell fate decisions [ca46_rna]

| PRJNA1072572 | ENA

Smarca4 (Brg1) is a haploinsufficient B-cell tumor suppressor that fine-tunes centrocyte cell fate decisions [ca46_atac]

Project description:Smarca4 (Brg1) is a haploinsufficient B-cell tumor suppressor that fine-tunes centrocyte cell fate decisions [ca46_atac]

| PRJNA1072578 | ENA

Smarca4 (Brg1) is a haploinsufficient B-cell tumor suppressor that fine-tunes centrocyte cell fate decisions [smarca4_rna]

Project description:Smarca4 (Brg1) is a haploinsufficient B-cell tumor suppressor that fine-tunes centrocyte cell fate decisions [smarca4_rna]

| PRJNA1072579 | ENA

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