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NCBP2 promotes colorectal cancer growth and metastasis by driving lipid droplet accumulation by stabilizing LIPG mRNA

ABSTRACT: NCBP2 promotes colorectal cancer growth and metastasis by driving lipid droplet accumulation by stabilizing LIPG mRNA

PROVIDER: PRJNA1126308 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29481529_1.fastq.gz	Fastqsanger.gz
	SRR29481529_2.fastq.gz	Fastqsanger.gz
	SRR29481530_1.fastq.gz	Fastqsanger.gz
	SRR29481530_2.fastq.gz	Fastqsanger.gz
	SRR29481531_1.fastq.gz	Fastqsanger.gz

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NCBP2 promotes colorectal cancer growth and metastasis by driving lipid droplet accumulation by stabilizing LIPG mRNA

Project description:RNA-binding proteins are critical for RNA processing and aberrantly expressed in colorectal cancer (CRC). In this study, by screening and bioinformatic analyses of the TCGA database and GSE20916 and GSE18105 datasets, NCBP2 was ultimately identified as a potential oncogene in CRC. We observed that NCBP2 was overexpressed in tumour tissues; its overexpression was correlated with CRC invasion and distant metastasis and indicated poorer survival in CRC patients. NCBP2 overexpression promoted the proliferation, migration and invasion of CRC cells in vitro and in vivo. Mechanistically, the NCBP2 protein stabilizes LIPG mRNA and increases LIPG expression via direct binding to m7G in the 5’-cap structure of LIPG mRNA. NCBP2 also facilitates lipid droplet accumulation in CRC cells in a LIPG-dependent manner. This study demonstrated that the NCBP2–LIPG–lipid droplet axis represents a new mechanism for CRC growth and distant metastasis and is a promising target for CRC treatment.

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Senescent glia link neuronal mitochondrial dysfunction and lipid droplet accumulation with age

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Senescent glia link neuronal mitochondrial dysfunction and lipid droplet accumulation with age [19082_28_MASTER]

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Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy

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