Project description:Salmonella is a common food-borne pathogen that is highly pathogenic and infectious, causing serious harm to livestock breeding and food safety. Uncovering the mechanisms of Salmonella infection and immune evasion can effectively prevent Salmonella contamination of livestock and poultry food. Here, small RNA sequencing results showed that exosomes produced by naïve murine macrophages RAW 264.7 cells contained a unique enrichment of a set of microRNAs (miRNAs) after Salmonella infection.RT-qPCR analysis verified that the tested miRNA (i.e. miR-27a-5p, miR-92a-1-5p and miR-1249-5p) showed similar expression patterns, consistent with small RNA sequencing data. The TargetScan database predicted that the most promising targets for the differentially expressed miRNAs were abundant in the immune system, infectious diseases and signal transduction pathways.
Project description:Polymyxin-resistant Salmonella was isolated from retail chicken samples in Shanghai, China. Genome sequencing was performed to study the polymyxin-resistant mechanism of Salmonella and ensure food safety.
| PRJNA1208761 | ENA
Project description:Characterization on Development Mechanisms of Colistin Resistance in Salmonella Isolates from Retail Meat in Shanghai, China
| PRJNA1261411 | ENA
Project description:Staphylococcus aureus isolated from retail food
Project description:The mechanisms of action of common food preservatives are poorly understood. As there is a drive to develop alternative preservatives, understanding the mechanisms of action of current preservatives can inform development of novel food preservatives to ensure their efficacy. Here we used TraDIS-Xpress, a large-scale, genome-wide unbiased screen to determine the mechanisms of action of common food preservatives by determining the genes that affect preservative susceptibility in Salmonella enterica serovar Typhimurium.
