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MiR-575 in exosomes of vaginal discharge is downregulated in ovarian cancer patients

ABSTRACT: miR-575 in exosomes of vaginal discharge is downregulated in ovarian cancer patients

PROVIDER: PRJNA1130533 | ENA |

REPOSITORIES: ENA

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miR-575 in exosomes of vaginal discharge is downregulated in ovarian cancer patients

Project description:We collected vaginal discharge from 30 ovarian cancer patients and 29 benign gynecological disease patients, extracted exosomal miRNAs, and examined the expression differences between groups by RT-qPCR.

2025-05-07 | GSE271256 | GEO

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Paraburkholderia caledonica strain:575 | isolate:DPS 575

Project description:Paraburkholderia caledonica 575 genome sequencing

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VEGF overexpressed mesoangioblasts enhance urethral and vaginal recovery following simulated vaginal birth in rats

Project description:Background: Vaginal birth causes injury to the pelvic floor and may lead to urinary incontinence. Cell therapy has been proposed to assist in functional recovery. Objective: To assess if intra-arterial injection of mesoangioblasts (MABs) or Vascular Endothelial Growth Factor (VEGF)-overexpressed MABs, improves urethral and vaginal function recovery after simulated vaginal delivery (SVD). Results: All stem-cell injected rats had external urethral sphincteric and vaginal function recovery within 14d, as compared to half of controls. Functional recovery was paralleled by improved muscle regeneration and microvascularization. Recovery was not different between autologous and allogenic MABs. MABsallo-VEGF accelerated functional recovery and increased GAP-43 expression at 7d. We detected early on in the recovery major transcriptional changes in both MABsallo and MABsallo-VEGF. MABSallo upregulated transcripts that encode proteins involved in myogenesis and dendrite development, and downregulated pro-inflammatory processes MABsallo-VEGF upregulated transcripts that encode proteins involved neuron and dendrite development and downregulates genes involved in hypoxia and oxidative stress. 7d after injury, Later MABsallo-VEGF showed a decrease in oxidative and inflammatory response compared to MABSallo treated urethras. These pathways are also downregulated in animals that have recovered at 7d, compared to non-recovered animals. Conclusion: Intra-arterial injection of MABsallo-VEGF enhances neuroregeneration and accelerates functional urethral and vaginal recovery after simulated vaginal delivery. Injection of stem cells induces faster recovery of urethral and vaginal function; cells overexpressing a factor increasing blood vessel formation, were even more effective.

2023-08-30 | GSE222561 | GEO

Phellinus igniarius strain:CCBS 575 | isolate:CCBS 575

Project description:Phellinus igniarius CCBS 575 Transcriptome - Pi

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Phellinus igniarius strain:CCBS 575 | isolate:CCBS 575

Project description:Phellinus igniarius CCBS 575 Standard Draft genome sequencing

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Methylorubrum extorquens strain:SLI 575

Project description:Methylorubrum extorquens SLI 575 genome sequencing

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Neurospora crassa strain:FGSC 575

Project description:Neurospora crassa strain:FGSC 575 Genome sequencing

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microRNA expression in vaginal melanoma

Project description:microRNA expression in RNA isolated from formalin fixed, paraffin embedded tissue from vaginal melanoma compared to adjacent healthy vaginal mucosa.

2022-07-16 | GSE208175 | GEO

mRNA expression in vaginal melanoma

Project description:mRNA expression in RNA isolated from formalin fixed, paraffin embedded tissue from vaginal melanoma compared to adjacent healthy vaginal mucosa.

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