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Fecal Microbiota Transplantation Alters Lung Transcriptome and Signaling Pathway

ABSTRACT: Fecal Microbiota Transplantation Alters Lung Transcriptome and Signaling Pathway

PROVIDER: PRJNA1130885 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29680181_1.fastq.gz	Fastqsanger.gz
	SRR29680181_2.fastq.gz	Fastqsanger.gz
	SRR29680182_1.fastq.gz	Fastqsanger.gz
	SRR29680182_2.fastq.gz	Fastqsanger.gz
	SRR29680183_1.fastq.gz	Fastqsanger.gz

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Fecal Microbiota Transplantation Alters Lung Transcriptome and Signaling Pathway

Project description:Rationale: Recent studies suggest a potential link between gut bacterial microbiota dysbiosis and PAH, but the exact role of gut microbial communities, including bacteria, archaea, and fungi, in PAH remains unclear. Objectives: To investigate the role of gut microbiota dysbiosis in idiopathic pulmonary arterial hypertension (IPAH) and to assess the therapeutic potential of fecal microbiota transplantation (FMT) in modulating PAH progression. Methods: Using shotgun metagenomics, we analyzed gut microbial communities in IPAH patients and healthy controls. FMT was performed to transfer gut microbiota from IPAH patients or MCT-PAH rats to normal rats and from healthy rats to MCT-PAH rats. Hemodynamic measurements, echocardiography, histological examination, metabolomic and RNA-seq analysis were conducted to evaluate the effects of FMT on PAH phenotypes. Measurements and Main Results: Gut microbiota analysis revealed significant alterations in the bacterial, archaeal, and fungal communities in IPAH patients compared to healthy controls. FMT from IPAH patients induced PAH phenotypes in recipient rats. Conversely, FMT from healthy rats to IPAH rats significantly ameliorated PAH symptoms, restored gut microbiota composition, and normalized serum metabolite profiles. Specific microbial species were identified with high diagnostic potential for IPAH, improving predictive performance beyond individual or combined microbial communities. Conclusions: This study establishes a causal link between gut microbiota dysbiosis and IPAH and demonstrates the therapeutic potential of FMT in reversing PAH phenotypes. The findings highlight the critical role of bacterial, archaeal, and fungal communities in PAH pathogenesis and suggest that modulation of the gut microbiome could be a promising treatment strategy for PAH.

2025-04-30 | GSE271297 | GEO

Impact of fecal microbiota transplantation (FMT) in 3 days-ABX-treated recipient mice using feces from 6 NSCLC patients at diagnosis.

Project description:This study aimed to analyze changes in gut microbiota composition in mice after transplantation of fecal microbiota (FMT, N = 6) from the feces of NSCLC patients by analyzing fecal content using 16S rRNA sequencing, 10 days after transplantation. Specific-pathogen-free (SPF) mice were used for each experiments (N=4) as controls.

2023-07-01 | E-MTAB-12812 | biostudies-arrayexpress

Fecal Microbiota Transplantation for Ulcerative Colitis.

Project description:Fecal Microbiota Transplantation for Ulcerative Colitis.

| PRJEB46777 | ENA

Fecal Microbiota Transplantation for Metabolic Syndrome

Project description:Fecal Microbiota Transplantation for Metabolic Syndrome

| PRJEB46778 | ENA

Fecal microbiota transplantation alleviates diabetes peripheral neuropathy

Project description:Fecal microbiota transplantation alleviates diabetes peripheral neuropathy

| PRJEB37479 | ENA

Fecal microbiota transplantation in irritable bowel syndrome patients

Project description:Fecal microbiota transplantation in irritable bowel syndrome patients

| PRJEB65418 | ENA

Profiling the colonic mucosal response to fecal microbiota transplantation

Project description:Colonic mucosal response to fecal microbiota transplantation

| PRJEB73377 | ENA

Fecal Microbiota Transplantation for refractory immune checkpoint inhibitor-associated colitis

Project description:We report the first case series of ICI associated colitis successfully treated with fecal microbiota transplantation (FMT), with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T cells (Tregs) within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis.

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Fecal Microbiota Transplantation for Extended-Spectrum Beta Lactamase Carriers.

Project description:Fecal Microbiota Transplantation for Extended-Spectrum Beta Lactamase Carriers.

| PRJEB46779 | ENA

Fecal microbiota transplant rescues mice from sepsis

Project description:The aim of this study was to test the hypothesis that replenishing the microbiota with a fecal microbiota transplant (FMT) can rescue a host from an advanced stage of sepsis. We developed a clinically-relevant mouse model of lethal polymicrobial gut-derived sepsis in mice using a 4-member pathogen community (Candida albicans, Klebsiella oxytoca, Serratia marcescens, Enterococcus faecalis) isolated from a critically ill patient. In order to mimic pre-operative surgical patient condition mice were exposed to food restriction and antibiotics. Approximately 18 hours prior to surgery food was removed from the cages and the mice were allowed only tap water. Each mouse received an intramuscular Cefoxitin injection 30 minutes prior to the incision at a concentration of 25 mg/kg into the left thigh. Mice were then subjected to a midline laparotomy, 30% hepatectomy of the left lateral lobe of the liver and a direct cecal inoculation of 200 µL of the four pathogen community. On postoperative day one, the mice were administered rectal enema. Mice were given either 1 ml of fecal microbiota transplant (FMT) or an autoclaved control (AC). This was again repeated on postoperative day two. Mice were then followed for mortality. Chow was restored to the cages on postoperative day two, approximately 45 hours after the operation. The injection of fecal microbiota transplant by enema significantly protected mice survival, reversed the composition of gut microflora and down-regulated the host inflammatory response. The cecum, left lobe of the liver, and spleen were isolated from mice for microarray processing with three or more replicates for six expermental conditions: non-treated control, SAHC POD1, SAHC.AC POD2, SAHC.FMT POD2, SAHC.AC POD7, SAHC.FMT POD7

2015-07-30 | E-GEOD-71530 | biostudies-arrayexpress

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