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RNA-sequncing in UUO-induced PTC-specific p300 knockout mouse kidneys

ABSTRACT: RNA-sequncing in UUO-induced PTC-specific p300 knockout mouse kidneys

PROVIDER: PRJNA1130890 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29682325.fastq.gz	Fastqsanger.gz
	SRR29682326.fastq.gz	Fastqsanger.gz
	SRR29682327.fastq.gz	Fastqsanger.gz
	SRR29682328.fastq.gz	Fastqsanger.gz
	SRR29682329.fastq.gz	Fastqsanger.gz

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RNA-sequncing in UUO-induced PTC-specific p300 knockout mouse kidneys

Project description:p300 was knockout in renal proximal tubule cells of mouse kidney. Mouse was sacrificed 8 days after UUO sugery

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Project description:Increased export of transglutaminase-2 (TG2) by tubular epithelial cells (TECs) into the surrounding interstitium modifies the extracellular homeostatic balance leading to fibrotic membrane expansion. Although silencing of extracellular TG2 ameliorates progressive kidney scarring in animal models of chronic kidney disease, the pathway through which TG2 is secreted from TECs and contributes to disease progression has not been elucidated. In this study, we developed a global proteomic approach to identify binding partners of TG2 responsible for TG2 externalization in kidneys subjected to unilateral ureteric obstruction, using TG2-knockout kidneys as negative controls. We report a robust and unbiased analysis of the membrane interactome of TG2 in fibrotic kidneys relative to the entire proteome post-UUO detected by SWATH-mass spectrometry.

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RNA sequencing of sham-operated and unilateral ureteral obstruction (UUO)-operated mouse kidneys in Pax8Cre+ and Kdm6afl/Y Pax8Cre+ knockout mice

Project description:RNA-sequencing of mouse left kidneys for which the left ureter was obstructed (UUO) or not obstructed (sham) animals, isolated 7 days after the surgery in normal mice and mice in which the Kdm6a gene was deleted from tubule epithelial cells

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