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Restriction of innate Tgd17 cell plasticity by an AP-1 regulatory axis [multiome]

ABSTRACT: Restriction of innate Tgd17 cell plasticity by an AP-1 regulatory axis [multiome]

PROVIDER: PRJNA1130938 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29686800.fastq.gz	Fastqsanger.gz
	SRR29686801.fastq.gz	Fastqsanger.gz
	SRR29686802_1.fastq.gz	Fastqsanger.gz
	SRR29686802_2.fastq.gz	Fastqsanger.gz
	SRR29686803_1.fastq.gz	Fastqsanger.gz

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Restriction of innate Tgd17 cell plasticity by an AP-1 regulatory axis [multiome]

Project description:IL-17-producing gd T (Tgd17) cells are innate-like mediators of intestinal barrier immunity. While Th17 cell and ILC3 plasticity have been extensively studied, the mechanisms governing Tgd17 cell effector flexibility remain undefined. Here, we combined type 3 fate-mapping with single cell ATAC/RNA-seq multiome profiling to define the cellular features and regulatory networks underlying Tgd17 cell plasticity. During homeostasis, Tgd17 cell effector identity was stable across tissues, including for intestinal T-bet+ Tgd17 cells that restrained IFNg production. However, S. typhimurium infection induced intestinal Vg6+ Tgd17 cell conversion into type 1 effectors, with loss of IL-17A production and partial RORgt downregulation. Multiome analysis revealed a trajectory along Vg6+ Tgd17 effector conversion, with TIM-3 marking ex-Tgd17 cells with enhanced type 1 functionality. Lastly, we characterized and validated a critical AP-1 regulatory axis centered around JunB and Fosl2 that controls Vg6+ Tgd17 cell plasticity by stabilizing type 3 identity and restricting type 1 effector conversion.

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Restriction of innate Tgd17 cell plasticity by an AP-1 regulatory axis [CUT&Run]

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Restriction of innate Tgd17 cell plasticity by an AP-1 regulatory axis

Project description:Restriction of innate Tgd17 cell plasticity by an AP-1 regulatory axis

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Restriction of innate Tgd17 cell plasticity by an AP-1 regulatory axis [CUT&Run]

Project description:Restriction of innate Tgd17 cell plasticity by an AP-1 regulatory axis [CUT&Run]

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Restriction of innate Tgd17 cell plasticity by an AP-1 regulatory axis

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-05-26 | GSE290581 | GEO

RNA Sequencing of Tgd17 progenitors

Project description:Tgd17 cells are critical immune effector cells that exit the thymus committed to peripheral IL-17 responses, but whether the development of cells into this lineage is pre-programmed or driven by instructive TCR signals is unresolved. Using newly generated reporter mice for a gene necessary for Tgd17 cell development, Sox13, we identified progenitor cells (known as DN1d cells) that expressed high levels of Sox13 prior to expression of the TCR. To interrogate whether DN1d cells could be a candidate Tgd17-biased progenitor, whole transcriptome RNA sequencing was performed on these progenitors as well as canonical T cell progenitors thought to generate all T cell subsets and the proposed progeny Tgd17 cells. The data demonstrated that DN1d cells most closely resemble Tgd17 cells at a transcriptome level, while canonical T cell progenitors were very different from both DN1d cells and Tgd17 cells. Further studies demonstrated that DN1d cells generated Tgd17 cells in developmental assays, and that the transcriptional signature of DN1d cells is established and maintained independently of TCR expression or signaling but is instead dependent on HMG transcription factors SOX13 and TCF1. Thus, T cell lineage identity can be pre-programmed at the progenitor level and is not necessarily specified by specific TCR signals.

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Effect of Aire deficiency on peripheral Tgd17 gene expression

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Single-cell RT-PCR analysis of Tgd17 progenitors

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