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Ripk1 is critical for preserving effector regulatory T cells and the suppressive transcriptional program in regulatory T cells

ABSTRACT: Ripk1 is critical for preserving effector regulatory T cells and the suppressive transcriptional program in regulatory T cells

PROVIDER: PRJNA1131354 | ENA |

REPOSITORIES: ENA

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Ripk1 is critical for preserving effector regulatory T cells and the suppressive transcriptional program in regulatory T cells (RNA-Seq)

Project description:Ripk1 plays an important role as a regulator of programmed cell death processes such as apoptosis and necroptosis, and is involved in the initiation of pro-inflammatory NF-kB signaling. Immune tolerance depends on the proper function and homeostasis of regulatory T cells. Here, we show that Treg-specific ablation of Ripk1 in mice leads to a reduction of Treg cells and spontaneous systemic autoimmunity. Using chimeric mice that allowed us to study Treg cells in the absence of inflammatory conditions, we observed a disadvantage of Ripk1-deficient compared to Ripk1-proficient Treg cells. Importantly, we did not observe impaired viability of the Ripk1-deficient Treg cells. Furthermore, single-cell RNA sequencing revealed that Ripk1 is required for the maintenance of the Treg cell transcriptional signature, which is essential for the suppressive function of Treg cells. Together, these findings highlight the fundamental role of Ripk1 in maintaining immune homeostasis by preserving the suppressive phenotype of Treg cells

2025-07-01 | GSE271414 | GEO

Ripk1 is critical for preserving effector regulatory T cells and the suppressive transcriptional program in regulatory T cells (scRNA-Seq)

2025-07-01 | GSE271415 | GEO

Ripk1 is critical for preserving effector regulatory T cells and the suppressive transcriptional program in regulatory T cells (scRNA-Seq)

Project description:Ripk1 is critical for preserving effector regulatory T cells and the suppressive transcriptional program in regulatory T cells (scRNA-Seq)

| PRJNA1131361 | ENA

Ripk1 is critical for preserving effector regulatory T cells and the suppressive transcriptional program in regulatory T cells (RNA-Seq)

Project description:Ripk1 is critical for preserving effector regulatory T cells and the suppressive transcriptional program in regulatory T cells (RNA-Seq)

| PRJNA1131362 | ENA

Ripk1 is critical for preserving effector regulatory T cells and the suppressive transcriptional program in regulatory T cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-07-01 | GSE271416 | GEO

RIPK1 protects naïve and regulatory T cells from TNFR1-induced apoptosis

Project description:The T cell population size is stringently controlled before, during, and after immune responses, as improper cell death regulation can result in autoimmunity and immunodeficiency. RIPK1 is an important regulator of peripheral T cell survival and homeostasis. However, whether different peripheral T cell subsets show a differential requirement for RIPK1 and which programmed cell death pathway they engage in vivo remains unclear. In this study, we used mesenteric lymph node (mLN) cells of Ripk1 KO mice, Ripk1/Casp8 double KO mice and their respective wild types to investigate this.

2024-06-20 | GSE260973 | GEO

Transcriptional profiles of PA1 teratoma cells transfected by RIPK1, RIPK2, RIPK3, or RIPK4

Project description:RIPK4 but not the related kinases RIPK1, RIPK2, and RIPK3 caused similar transcriptional changes to Wnt3a. PA1 cells were transfected by 8ug RIPK1, RIPK2, RIPK3, or RIPK4 for 48h, RNA were extracted and sequenced.

2013-02-04 | E-GEOD-43362 | biostudies-arrayexpress

RIPK1 protects naïve and regulatory T cells from TNFR1-induced apoptosis

Project description:RIPK1 protects naïve and regulatory T cells from TNFR1-induced apoptosis

| PRJNA1084758 | ENA

Quantitative Transcriptome Analysis of RIPK1-KO CD4 T cells

Project description:RIPK1 is a key signaling molecule controlling cell death and inflammation through both scaffold and kinase functions of RIPK1. Human RIPK1 deficiency causes immunodeficiency and inflammatory diseases. Here we analyzed the functional roles of RIPK1 in CD4 T cells.

2022-02-27 | GSE197232 | GEO

Foxp1 is critical for the maintenance of regulatory T-cell homeostasis and suppressive function

Project description:Regulatory T (Treg) cells play central roles in maintaining immune homeostasis and self-tolerance. However, the molecular mechanisms underlying Treg cell homeostasis and suppressive function are still not fully understood. Here, we report that the deletion of another P subfamily members of the forkhead box (Foxp) subfamily member Foxp1 in Treg cells led to increased numbers of activated Treg (aTreg) cells at the expense of quiescent Treg cells, and also resulted in impaired Treg suppressive function. Mice with Foxp1-deficient Treg cells developed spontaneous inflammatory disease with age; they also had more severe inflammatory disease in colitis and experimental autoimmune encephalomyelitis (EAE) models. Mechanistically, we found that Foxp1 bound to the conserved noncoding sequence 2 (CNS2) element of the Foxp3 locus and helped maintain Treg suppressive function by stabilizing the Foxp3 expression. Furthermore, we found that Foxp1 and Foxp3 coordinated the regulation of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) expression levels. Taken together, our study demonstrates that Foxp1 plays critical roles in both maintaining Treg cell quiescence during homeostasis and regulating Treg suppressive function.

2019-04-10 | GSE121251 | GEO

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