Project description:Tumor microenvironment heterogeneity sheltered our understanding of papillary thyroid cancer. However, molecular characteristics of papillary thyroid cancer has not been reported at single cell resolution. The immunological link between papillary thyroid cancer and Hashimoto's thyroiditis is also in doubt.We identified 24 cell clusters in human papillary thyroid cancer based on their heterogeneous gene expression pattern. Follicular epithelial cell subsets in papillary thyroid cancer with Hashimoto's thyroiditis and papillary thyroid cancer without Hashimoto's thyroiditis showed different malignant level. Machine learning model identified potential biomarker to evaluate tumor epithelial cell development. Together with immunostaining, lymphocytes heterogeneity indicated an obvious B cell infiltration pattern in papillary thyroid cancer with Hashimoto's thyroiditis. Additionally, trajectory analysis of B cell and plasma cell suggest the migration potential from normal adjacent tissue of Hashimoto's thyroiditis to papillary thyroid cancer tissue. Our results provide the first single cell landscape of Papillary thyroid cancer. Single cell data resource of Papillary thyroid cancer with Hashimoto's thyroiditis promote our understanding of molecular heterogeneity and immunological link between papillary thyroid cancer and Hashimoto's thyroiditis.
Project description:Hashimoto's thyroiditis and papillary thyroid cancer are the most common thyroid disorders. We used spatial transcriptome sequencing (ST-seq) to investigate their potential relationship.
2024-06-27 | GSE230424 | GEO
Project description:RNA-based transcriptomic gene fusion analysis in Hashimoto's thyroiditis
Project description:To understand Hashimoto's Thyroiditis and translate this knowledge to clinical applications, we took mass spectrometric analysis on thyroid tissue fine-needle puncture from HT patients and healthy people in an attempt to make a further understanding of the pathogenesis of Hashimoto's Thyroiditis.
Project description:Spatial transcriptome gene expression profile in 2 patients with Hashimoto's thyroiditis and 2 patients with papillary thyroid cancer combined with Hashimoto's thyroiditis.
| PRJNA961115 | ENA
Project description:Genomic Profiling of Hashimoto's Thyroiditis using Next Generation Sequencing
| PRJNA948713 | ENA
Project description:Study on related genes of Hashimoto's thyroiditis and thyroid papillary carcinoma
Project description:Papillary thyroid carcinoma, as a malignant tumor with high incidence, is often accompanied by Hashimoto's thyroiditis. The pathogenesis of papillary thyroid carcinoma has not been fully clarified, and new molecular diagnostic methods are urgently needed to help the early and accurate diagnosis. In this study, the proteomic characteristics of papillary thyroid carcinoma in the context of Hashimoto's thyroiditis were analyzed by mass spectrometry, and the corresponding differential proteins and key pathways were screened to further study the pathogenesis and development mechanism.
