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RNA sequencing of nasal airway epithelial cells from preterm birth survivors at one year of age

ABSTRACT: RNA sequencing of nasal airway epithelial cells from preterm birth survivors at one year of age

PROVIDER: PRJNA1136398 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29841039.fastq.gz	Fastqsanger.gz
	SRR29841040.fastq.gz	Fastqsanger.gz
	SRR29841041.fastq.gz	Fastqsanger.gz
	SRR29841042.fastq.gz	Fastqsanger.gz
	SRR29841043.fastq.gz	Fastqsanger.gz

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RNA sequencing of nasal airway epithelial cells from preterm birth survivors at one year of age

Project description:To investigate potential drivers of respiratory disease in survivors of preterm birth by examining the transcriptomic profile of airway epithelial cells at approximately one year of age. Nasal airway epithelial brushings were collected, and primary cell cultures established from 8 term (GA>37w, 3.0 ± 1.1 years at collection) and 11 preterm participants (GA 25-31.2 weeks, 1.4 ± 0.1 years at collection). RNA was extracted from cultured cells and bulk RNA sequencing performed on both the ex vivo and in vitro samples.

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Project description:Preterm birth is the major cause of newborn and infant mortality affecting nearly one in every ten live births. This study was designed to develop an epigenetic biomarker for susceptibility of preterm birth using buccal cells from the mother, father, and child (triads). MeDIP-seq was used to identify differential DNA methylation regions (DMRs) using a comparison of control term birth versus preterm birth triads. Epigenetic DMR associations with preterm birth were identified for both the mother and father that were distinct and suggest potential epigenetic contributions from both parents. The mother (165 DMRs) and female child (136 DMRs) at p<1e-04 had the highest number of DMRs and were highly similar suggesting potential epigenetic inheritance of the epimutations. The male child had negligible DMR associations. The DMR associated genes for each group involve previously identified preterm birth associated genes.

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