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RNA sequencing of nasal airway epithelial cells from preterm birth survivors at one year of age

ABSTRACT: RNA sequencing of nasal airway epithelial cells from preterm birth survivors at one year of age

PROVIDER: PRJNA1136398 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29841039.fastq.gz	Fastqsanger.gz
	SRR29841040.fastq.gz	Fastqsanger.gz
	SRR29841041.fastq.gz	Fastqsanger.gz
	SRR29841042.fastq.gz	Fastqsanger.gz
	SRR29841043.fastq.gz	Fastqsanger.gz

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RNA sequencing of nasal airway epithelial cells from preterm birth survivors at one year of age

Project description:To investigate potential drivers of respiratory disease in survivors of preterm birth by examining the transcriptomic profile of airway epithelial cells at approximately one year of age. Nasal airway epithelial brushings were collected, and primary cell cultures established from 8 term (GA>37w, 3.0 ± 1.1 years at collection) and 11 preterm participants (GA 25-31.2 weeks, 1.4 ± 0.1 years at collection). RNA was extracted from cultured cells and bulk RNA sequencing performed on both the ex vivo and in vitro samples.

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Analysis of epigenetic changes in survivors of preterm birth reveals the effect of gestational age and evidence for a long term legacy

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Project description:Preterm birth is the leading cause of infant mortality resulting in over one million neonatal deaths annually. Maternal urinary tract infection (UTI) during pregnancy increases risk for preterm birth; however, biological processes mediating UTI-associated preterm birth are not well-described. We established a murine maternal UTI model in which challenge with uropathogenic E. coli resulted in preterm birth in about half of dams. Dams experiencing preterm birth displayed excessive bladder inflammation and altered uteroplacental T cell polarization compared to non-laboring infected dams, with no differences in bacterial burdens. Additional factors associated with preterm birth included higher proportions of male fetuses and lower maternal serum IL-10. Furthermore, exogenous maternal IL-10 treatment absolved UTI-associated preterm birth but contributed to fetal growth restriction in this model.

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