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Study of kidney state in 70% liver resection in experiment in mice

ABSTRACT: Study of kidney state in 70% liver resection in experiment in mice

PROVIDER: PRJNA1137338 | ENA |

REPOSITORIES: ENA

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Study of kidney state in 70% liver resection in experiment in mice

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Effect of splenectomy on liver regeneration after 70% resection in a mouse model.

Project description:In this work, the effect of splenectomy on liver regeneration was studied. For this purpose in the animals were reproduced splenectomy, and after 7 days 70% liver resection was performed. Animals in which the spleen was intact and only 70% liver resection was performed served as a comparison group. Animals in which only the spleen was removed also served as controls. The animals were removed from the experiment after 24 hours, 3 and 7 days. Macrophages were isolated from the livers of control animals as well as from the liver after 70% resection by magnetic sorting using the F4/80 marker. RNA was isolated from the obtained macrophages and used for transcriptome analysis. Macrophages in the regenerating liver were transcriptomically enriched for signaling pathways associated with monocyte migration, cell adhesion and cell death.

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Gene expression profile, population of macrophages and lymphocytes of the spleen in conditions of liver regeneration after 70% resection in mice

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Project description:In this work, the effect of splenectomy on liver regeneration was studied. For this purpose in 1 series of experiments the animals were reproduced splenectomy, and after 7 days 70% liver resection was performed. It was found that spleen removal leads to a decrease in the migration of Ly6C+ monocytes into the regenerating liver. Using transcriptional analysis it was shown that spleen and peripheral blood monocytes differ in the expression of genes associated with the synthesis of surface receptors necessary for cell migration. The obtained data explain the reason for the preferential migration of spleen monocytes rather than peripheral blood monocytes into the regenerating liver.

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