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Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Xenon in APPPS1 IFNy blocker-Mice]

ABSTRACT: Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Xenon in APPPS1 IFNy blocker-Mice]

PROVIDER: PRJNA1137962 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29897767_1.fastq.gz	Fastqsanger.gz
	SRR29897767_2.fastq.gz	Fastqsanger.gz
	SRR29897768_1.fastq.gz	Fastqsanger.gz
	SRR29897768_2.fastq.gz	Fastqsanger.gz
	SRR29897769_1.fastq.gz	Fastqsanger.gz

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Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Xenon in IFNy blocker - mice]

Project description:Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Xenon in IFNy blocker - mice]

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Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Xenon in APPPS1 - Mice]

Project description:Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Xenon in APPPS1 - Mice]

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Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Xenon in APPPS1 IFNy blocker-Mice]

Project description:Alzheimer’s disease (AD) is the most prevalent neurodegenerativedisorder. Currently, anti-amyloid antibody treatments modestly slow disease progression in milddementia due to AD.Emerging evidence shows that homeostatic dysregulation of the brainimmune system, especially that orchestrated by microglia, plays a significant role in the onset andprogression of the disease, including an increase in neuroinflammation and oxidative stress.Thus,a major question is how to modulate the phenotype and function of microglia to treat AD.Xenongas (Xe) is a noble gas used in human patients as an anesthetic and neuroprotectant in treatingbrain injuries. Xe penetratestheblood-brain barrier, which can make it an effective therapeutic.WeidentifiedthatXeinhalationpolarizesmouse and human microglia towards an intermediatestate of activation that we have termedas‘pre-MGnD’ in anacute neurodegeneration model andmouse models with AD-like pathology, i.e.,5xFAD (amyloid) and P301S (tau). This microglialphenotypic transition enhanced amyloid plaque compaction and reduced dystrophic neurites.Moreover, Xe inhalation reduced brain atrophy neuroinflammationand improved nest-buildingbehavior in APOE4:P301S mice. Mechanistically, Xe inhalation polarizes homeostatic microgliatoward a pre-MGnD state via IFNsignaling that maintains the microglial phagocytic responsewhile suppressing its pro-inflammatory properties. These resultssupport the translation of Xeinhalation as a novel approach to treatingAD.

2025-01-15 | GSE272684 | GEO

Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Xenon in IFNy blocker - mice]

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Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Xenon scRNAseq Myeloid]

Project description:Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Xenon scRNAseq Myeloid]

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Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Xenon-iMGL in vitro]

Project description:Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Xenon-iMGL in vitro]

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Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Xenon in IPSMG H5xFAD]

Project description:Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Xenon in IPSMG H5xFAD]

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Project description:Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Xenon in IFNgr1 cKO]

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Single nucleus RNA sequencing of the cortex of antibiotic and vehicle treated APPPS1-21 mice

Project description:Previously, we and others have shown that broad spectrum antibiotic treatment from postnatal day 14-21 reduces neuroinflammation in the APPPS1-21 model of AD-related amyloidosis. In the current study, we used single-nucleus RNA sequencing (snRNAseq) to assess cell-type specific transcriptional changes in antibiotic treated mice and controls. We also assessed changes in astrocyte subclusters in these groups.

2025-05-01 | GSE295459 | GEO

Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Xenon PD in MGnD paradigm]

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