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Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice

ABSTRACT: Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice

PROVIDER: PRJNA1138415 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29907351.fastq.gz	Fastqsanger.gz
	SRR29907352.fastq.gz	Fastqsanger.gz
	SRR29907353.fastq.gz	Fastqsanger.gz
	SRR29907354.fastq.gz	Fastqsanger.gz
	SRR29907355.fastq.gz	Fastqsanger.gz

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Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice

2024-08-20 | GSE272719 | GEO

Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice.

Project description:Genetic variation is known to contribute to the variation of animal social behavior, but the molecular mechanisms that lead to behavioral differences are still not fully understood. Here, we investigate the cellular evolution of the hypothalamic preoptic area (POA), a brain region that plays a critical role in social behavior, across two sister species of deer mice (Peromyscus maniculatus and P. polionotus) with divergent social systems. These two species exhibit large differences in mating and parental care behavior across species and sex. Using single-nucleus RNA-sequencing, we build a cellular atlas of the POA for males and females of both Peromyscus species. We identify four cell types that are differentially abundant across species, two of which may account for species differences in parental care behavior based on known functions of these cell types. Our data further implicate two sex-biased cell types to be important for the evolution of sex-specific behavior. Finally, we show a remarkable reduction of sex-biased gene expression in P. polionotus, a monogamous species that also exhibits reduced sexual dimorphism in parental care behavior. Our POA atlas is a powerful resource to investigate how molecular neuronal traits may be evolving to give rise to innate differences in social behavior across animal species.

| S-EPMC11383002 | biostudies-literature

Evolution of gene expression across brain regions in behaviorally divergent deer mice

Project description:Evolution of gene expression across brain regions in behaviorally divergent deer mice

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scRNAseq to understand hormonal control on pubertal transcription in the medial preoptic area

Project description:Pubertal maturation aids developments in emotion, cognition and reproduction. The conserved roles of elevated circulating gonadal sex steroids for the continued maturation of the nervous system via steroid hormone receptor mediated gene regulation is well documented. However, critical transcriptional dynamics mediated by steroids throughout puberty in molecularly defined circuitry remains elusive. We investigated pubertal transcriptional dynamics in the medial preoptic area (MPOA), a hypothalamic center for reproductive behaviors, in male and female mice at single cell resolution (scRNAseq).

2025-11-13 | GSE172177 | GEO

Transcription profiling of mouse bed nucleus of the stria terminalis and medial preoptic area

Project description:The effect of photoperiod on gene expression was assessed in punch samples of the bed nucleus of the stria terminalis and medial preoptic area. Long day mice were housed in 16L:8D and short day mice were housed in 8L:16D. Experiment Overall Design: For the medial preoptic area, independent samples were collected from long day (n=3) and short day (n=3) mice. For the bed nucleus of the stria terminalis independent samples were collected from long day (n=3) and short day (n=2) mice.

2008-06-14 | E-GEOD-5795 | biostudies-arrayexpress

Glucoregulatory responses to hypothalamic preoptic area cooling.

Project description:Normal glucose homeostasis depends on the capacity of pancreatic β-cells to adjust insulin secretion in response to a change of tissue insulin sensitivity. In cold environments, for example, the dramatic increase of insulin sensitivity required to ensure a sufficient supply of glucose to thermogenic tissues is offset by a proportionate reduction of insulin secretion, such that overall glucose tolerance is preserved. That these cold-induced changes of insulin secretion and insulin sensitivity are dependent on sympathetic nervous system (SNS) outflow suggests a key role for thermoregulatory neurons in the hypothalamic preoptic area (POA) in this metabolic response. As these POA neurons are themselves sensitive to changes in local hypothalamic temperature, we hypothesized that direct cooling of the POA would elicit the same glucoregulatory responses that we observed during cold exposure. To test this hypothesis, we used a thermode to cool the POA area, and found that as predicted, short-term (8-h) intense POA cooling reduced glucose-stimulated insulin secretion (GSIS), yet glucose tolerance remained unchanged due to an increase of insulin sensitivity. Longer-term (24-h), more moderate POA cooling, however, failed to inhibit GSIS and improved glucose tolerance, an effect associated with hyperthermia and activation of the hypothalamic-pituitary-adrenal axis, indicative of a stress response. Taken together, these findings suggest that POA cooling is sufficient to recapitulate key glucoregulatory responses to cold exposure.

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Acute (2 hr) response to rxLeptin injection in preoptic area/hypothalamus/pituitary of juvenile Xenopus laevis

Project description:Leptin binding to the leptin receptor (LepR) causes rapid signaling to the nucleus. We investigated the early (2 hr) transcriptional response to acute leptin injectio (intracerebroventricular) in the preoptic area/hypothalamus/pituitary of juvenile Xenopus laevis frogs. Frogs were given i.c.v. injections of 0.6% saline or recombinant X. laevis leptin (rxLeptin; 20 ng/g BW) and 2 hrs later killed and the preoptic area/hypothalamus/pituitary dissected.

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Project description:Molecular, Spatial and Functional Single-Cell Profiling of the Hypothalamic Preoptic Region

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Bulk single nuclear sequencing in the ventral medial preoptic area

Project description:Single nuclear RNA-sequencing from tissue dissected from the ventral medial preoptic area (VMPO) of the hypothalamus in saline and LPS injected mice

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Genetic markers for temperature-sensitive neurons in mouse preoptic area

Project description:This study combined single-cell RNA-seq with whole-cell patch-clamp recording to profile the neurons in mouse preoptic area with characterized temperature-sensitivity

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