Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Hypoxia promotes airway differentiation in the human lung epithelium [Bulk RNA-seq]

ABSTRACT: Hypoxia promotes airway differentiation in the human lung epithelium [Bulk RNA-seq]

PROVIDER: PRJNA1139139 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Hypoxia promotes airway differentiation in the human lung epithelium

Project description:Hypoxia promotes airway differentiation in the human lung epithelium

| PRJNA1140142 | ENA

Hypoxia promotes airway differentiation in the human lung epithelium [Bulk RNA-seq]

Project description:Human embryos develop under physiological hypoxia, but how hypoxia directly affects human organogenesis remains unknown. We have investigated the effects of hypoxia on human lung epithelia using organoids. First trimester lung epithelial progenitors remain undifferentiated under normoxia, but initiate spontaneous differentiation towards multiple airway cell types, and inhibit alveolar differentiation under hypoxia. Genetic and chemical manipulation experiments showed that these effects were dependent on HIF (Hypoxia-Inducible Factor) activity, with HIF1α and HIF2α differentially regulating progenitor fate decisions. We identified the cell fate-determining transcription factors KLF4/KLF5 and ASCL1 as direct targets of the HIF pathway, promoting progenitor differentiation to basal and neuroendocrine cells respectively. Chronic hypoxia also induces transdifferentiation of human alveolar type 2 cells into airway cells via the HIF pathway, suggesting that the developmental response to hypoxia is conserved into adulthood and potentially contributes to chronic lung disease.

2025-07-31 | GSE272860 | GEO

Hypoxia promotes airway differentiation in the human lung epithelium

2025-07-31 | GSE273089 | GEO

Hypoxia promotes airway differentiation in the human lung epithelium [DamID-seq]

Project description:Hypoxia promotes airway differentiation in the human lung epithelium [DamID-seq]

| PRJNA1139137 | ENA

Hypoxia promotes airway differentiation in the human lung epithelium [DamID-seq]

2025-07-31 | GSE272859 | GEO

Down Syndrome Airway Epithelium Bulk RNA-seq Analysis

Project description:Down Syndrome Airway Epithelium Bulk RNA-seq Analysis

| PRJNA817270 | ENA

Gene expression of normal airway epithelium and squamous in homeostasis.

Project description:Bulk RNA sequencing analysis was performed to investigate transcriptional profiles in normal airway epithelium and squamous.

2023-03-20 | GSE227433 | GEO

Transcriptome Analysis in Peripheral Airway Epithelium of Distinct Lung microbiome

Project description:In this study, we assessed lower airway microbiome from a cohort of patients to determine whether specific microbiome taxa correlate with with specific metabolic activities. In a subset of 12 patients, transcriptomic expression were analyzed to compare host mucosa immune response We collected peripheral airway brushings from the 12 subjects whose lung microbiome were analyzed; Total RNA were obtained from the peripheral airway epithelium.

2016-03-29 | E-GEOD-73585 | biostudies-arrayexpress

Analysis of normal human lung small and large airway epithelium.

Project description:Single cell RNA sequencing of normal human lung airway epithelium

2020-12-16 | GSE160664 | GEO

Airway Epithelium and Model Systems

Project description:Airway Epithelium and Model Systems

| PRJNA740070 | ENA