Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Olig1/2 Coordinately Control Oligodendrocyte Versus Interneuron Fate Acquisition in Normal Brain and H3.3G34R/V-mutant Gliomas

ABSTRACT: Olig1/2 Coordinately Control Oligodendrocyte Versus Interneuron Fate Acquisition in Normal Brain and H3.3G34R/V-mutant Gliomas

PROVIDER: PRJNA1140536 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR30004039_1.fastq.gz	Fastqsanger.gz
	SRR30004039_2.fastq.gz	Fastqsanger.gz
	SRR30004040_1.fastq.gz	Fastqsanger.gz
	SRR30004040_2.fastq.gz	Fastqsanger.gz
	SRR30004041_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Olig1/2 Coordinately Control Oligodendrocyte Versus Interneuron Fate Acquisition in Normal Brain and H3.3G34R/V-mutant Gliomas

Project description:The co-opting of the developmental gliogenesis program is a hallmark characteristic of glioblastoma (GBM). The bHLH transcription factors Olig1/2 are co-expressed in tri-potential intermediate progenitors (tri-IPCs) and GBM cells, yet their functions in these cells remain largely unknown. Here, we demonstrate that Olig1/2 coordinately promote the generation of oligodendrocytes while repressing the generation of olfactory bulb interneurons in tri-IPCs and GBM. Mechanistically, Olig1/2 directly bind to multiple enhancers, such as hs687, DSG (downstream from Gsx2) and a putative enhancer to regulate the expression of Gsx2, thereby regulating the fate determination process of tri-IPCs during gliogenesis. Furthermore, we provide compelling evidence that human histone H3.3G34R/V-mutation tumors, a subtype of pediatric high-grade gliomas, originate from cortical-derived tri-IPCs. Altogether, our findings suggest that the molecular mechanism of Olig1/2 in gliogenesis and gliomagenesis are conserved, which will deepen our understanding of the gaps between normal development and tumorigenesis.

2024-08-10 | GSE273171 | GEO

Expression analysis of neural stem cells isolated from Olig1-wt and Olig1-ko embryos

Project description:Olig1 is a bHLH transcription factor which is important for Oligodendrocyte development We used microarray profiling to assess which genes are differentially expressed in absence of Olig1 in neural stem cells. Neural stem cells were isolated from ganglionic eminences of E14.5 wild-type and Olig1-KO brains. The cells were cultured in serum-free neural stem cell media and RNA extracted.

2012-07-27 | E-GEOD-39706 | biostudies-arrayexpress

Expression analysis of neural stem cells isolated from Olig1-wt and Olig1-ko embryos

2012-07-28 | GSE39706 | GEO

Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development

Project description:Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development

| PRJNA344717 | ENA

Olig1

Project description:Rattus norvegicus Olig1, oligodendrocyte transcription factor 1 [Source:RGD Symbol;Acc:621129], is differentially expressed in 10 experiment(s);

| ENSRNOG00000028648 | ExpressionAtlas

Olig1

Project description:Rattus norvegicus Olig1, oligodendrocyte transcription factor 1 [Source:RGD Symbol;Acc:621129], is expressed in 4 baseline experiment(s);

| ENSRNOG00000028648 | ExpressionAtlas

OLIG1

Project description:Oryctolagus cuniculus OLIG1, oligodendrocyte transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:16983], is expressed in 1 baseline experiment(s);

| ENSOCUG00000027389 | ExpressionAtlas

OLIG1

Project description:Equus caballus OLIG1, oligodendrocyte transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:16983], is expressed in 1 baseline experiment(s);

| ENSECAG00000037026 | ExpressionAtlas

OLIG1

Project description:Homo sapiens OLIG1, oligodendrocyte transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:16983], is expressed in 30 baseline experiment(s);

| ENSG00000184221 | ExpressionAtlas

OLIG1

Project description:Sus scrofa OLIG1, oligodendrocyte transcription factor 1 [Source:VGNC Symbol;Acc:VGNC:91035], is differentially expressed in 1 experiment(s);

| ENSSSCG00000012040 | ExpressionAtlas

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data