Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Programmed cell death-1 receptor deficiency enhances CD30+ T regulatory cell function in Melanoma [Murine scRNAseq]

ABSTRACT: Programmed cell death-1 receptor deficiency enhances CD30+ T regulatory cell function in Melanoma [Murine scRNAseq]

PROVIDER: PRJNA1142058 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR30046136_1.fastq.gz	Fastqsanger.gz
	SRR30046136_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

Programmed cell death-1 receptor deficiency enhances CD30+ T regulatory cell function in Melanoma [Murine scRNAseq]

Project description:Regulatory T cells (Tregs) are vital for immune suppression rendering their function through multiple pathways including the expression of co-inhibitory receptors. The role of co-receptors namely PD1 in Treg function remains controversial. We demonstrate that PD1 is a master checkpoint in Tregs controlling several aspects of Treg biology in tumor immunity. Our data demonstrates that PD1 controls the expression and function of a unique co-inhibitory receptor network that dictates Treg function. We found that CD30 plays a central role within this network in driving Treg suppressive function within the tumor microenvironment (TME). Mechanistically, PD1 deficiency unleashed enhanced STAT5 signaling in Tregs, which drove CD30 expression. Our work highlights a new role for PD1 as a checkpoint that negatively controls CD30 expression in Tregs thereby dampening their function. Understanding the landscape changes that PD1 renders to Treg function can enable the use of combination therapies for better treatment outcomes in cancer.

2025-04-09 | GSE273532 | GEO

Programmed cell death-1 receptor deficiency enhances CD30+ T regulatory cell function in Melanoma [Murine NanoString CosMx SMI]

Project description:Programmed cell death-1 receptor deficiency enhances CD30+ T regulatory cell function in Melanoma [Murine NanoString CosMx SMI]

| PRJNA1142060 | ENA

Programmed cell death-1 receptor deficiency enhances CD30+ T regulatory cell function in Melanoma [Murine NanoString CosMx SMI]

2025-04-09 | GSE273530 | GEO

Extraembryonic gut endoderm cells undergo programmed cell death during development

Project description:Extraembryonic gut endoderm cells undergo programmed cell death during development

| PRJNA1051994 | ENA

Extraembryonic gut endoderm cells undergo programmed cell death during development (RRBS)

Project description:Extraembryonic gut endoderm cells undergo programmed cell death during development (RRBS)

| PRJNA1052616 | ENA

Extraembryonic gut endoderm cells undergo programmed cell death during development (WGBS)

Project description:Extraembryonic gut endoderm cells undergo programmed cell death during development (WGBS)

| PRJNA1052619 | ENA

Transcriptome analysis of programmed cell death during allorecognition in Cryphonectria parasitica

Project description:Transcriptome analysis of programmed cell death during allorecognition in Cryphonectria parasitica

| PRJNA666425 | ENA

A decision point between transdifferentiation and programmed cell death priming controls

Project description:A decision point between transdifferentiation and programmed cell death priming controls

| PRJNA1190954 | ENA

Regorafenib Plus Programmed Cell Death-1 (PD-1) Inhibitors in Patients With Advanced Colorectal Cancer

Project description:This is a multicenter observational study aimed to describe the efficacy and safety of regorafenib plus programmed cell death-1 (PD-1) inhibitors in Chinese patients with advanced colorectal cancer in routine clinical practice. The primary end point is overall survival. The secondary endpoints include progression-free survival, objective response rate, disease control rate and the incidence of treatment-related adverse events.

| 2368689 | ecrin-mdr-crc

Comprehensive glycomic and glycoproteomic analysis of human programmed cell death protein 1 extracellular domain

Project description:Mass spectrometric analyses of N- and O-glycosylation on human programmed cell death protein 1 extracellular domain (hPD-1 ECD) that expressed by human embryonic kidney 293 (HEK 293) and Chinese hamster ovary (CHO) cells

2024-01-11 | PXD048448 |

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data