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Omics score: 0

Mus musculus

ABSTRACT: Differentially regulated genes in control and c-myc N-myc deficient LT-HSCs

OTHER RELATED OMICS DATASETS IN: GSE12538

PROVIDER: PRJNA114221 | ENA |

REPOSITORIES: ENA

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Project description:Differentially regulated genes in control and c-myc N-myc deficient LT-HSCs and progenitors

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Project description:Differentially regulated genes in control and c-myc N-myc deficient progenitors

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Project description:Differentially regulated genes in LT-HSC from control or Pbx1-null mice

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Project description:Differentially regulated genes in normal LT-HSC vs ST-HSC

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Project description:Expression data from control and LRF (leukemia/lymphoma related factor)-deficient mouse LT-HSCs

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Expression data from Mus musculus Myc-null heart at E13.5

Project description:We created mice, which are deficient for Myc specifically in cardiac myocytes by crossing crossed Myc-floxed mice (Mycfl/fl) and MLC-2VCre/+ mice. Serial analysis of earlier stages of gestation revealed that Myc-deficient mice died prematurely at E13.5-14.5. Morphological analyses of E13.5 Myc-null embryos showed normal ventricular size and structure; however, decreased cardiac myocyte proliferation and increased apoptosis was observed. BrdU incorporation rates were also decreased significantly in Myc-null myocardium. Myc-null mice displayed a 3.67-fold increase in apoptotic cardiomyocytes by TUNEL assay. We examined global gene expression using oligonucleotide microarrays. Numerous genes involved in mitochondrial death pathways were dysregulated including Bnip3L and Birc2. Keywords: wildtype vs Myc-null

2007-06-30 | GSE7162 | GEO

Differentially regulated genes in control and c-myc N-myc deficient LT-HSCs

Project description:Analysis of HSCs from control and c-myc N-myc deficient long-term hematopoietic stem cells. HSCs lacking both c-myc and N-myc display increased apoptosis rates. Data provide insight into the molecular changes occuring upon complete loss of Myc activity, clarifying the resulting apoptotic mechanism and the role of Myc family proteins in HSCs. LT-HSC (Lin-Sca1+CD150+CD48-) cells were sorted from the BM of MxCre c-myc flox2 N-myc flox2 (experimental) and c-myc flox2 N-myc flox2 (control) mice 3 days after the last pI-pC injection. Each condition was analysed in triplicates, with each replicate consisting of a pool of 3 dKO mice or 2 control mice.

2009-02-20 | E-GEOD-12467 | biostudies-arrayexpress

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Project description:Analysis of differentially expressed genes in murine Satb1-deficient hematopoietic stem cells (HSCs) compared to wild-type HSCs

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Identification of Fam122a regulated genes in LT-HSCs.

Project description:Identification of Fam122a regulated genes in LT-HSCs.

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Project description:Identification of Sin3B regulated genes in HSCs

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