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Secretory IgA dysfunction underlies poor prognosis in Fusobacterium-infected colorectal cancer

ABSTRACT: Secretory IgA dysfunction underlies poor prognosis in Fusobacterium-infected colorectal cancer

PROVIDER: PRJNA1142424 | ENA |

REPOSITORIES: ENA

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Secretory IgA dysfunction underlies poor prognosis in Fusobacterium-infected colorectal cancer

Project description:Fusobacterium nucleatum (Fn), enriched in human colorectal cancer (CRC), is linked to a worse prognosis. To uncover the cellular and molecular mechanisms behind this Fn-associated prognostic effect, we conducted single-cell transcriptomic analyses on 42 surgically removed colon tissues from newly diagnosed colon cancer patients. Through single-cell and spatial transcriptome data analyses, we found that the development of IgA plasma cells producing functional secretory IgA was impaired due to disrupted communications between IgA plasma cells and macrophages in Fn-positive CRC. Additionally, we identified a dysregulated IgA maturation (IGAM) module in Fn-positive patients, indicating compromised IgA-mediated mucosal immunity. This finding was further supported by observed increases in bacterial infiltration within tumors of Fn-positive patients. Remarkably, we were able to stratify Fn-positive patients based on IGAM activity, which could lead to novel treatment strategies for Fn-positive CRC patients. Our findings indicate that impaired secretory IgA activity by Fn infection increases the bacterial burden within tumors and worsens prognosis through chronic inflammation. Additionally, identifying a novel gene expression biomarker for stratifying Fn-positive patients promises to refine CRC treatment strategies, offering a more tailored approach to patient care.

2025-07-23 | GSE273567 | GEO

Secretory IgA dysfunction underlies poor prognosis in Fusobacterium-infected colorectal cancer [normal colon tissue]

2025-07-23 | GSE288951 | GEO

Secretory IgA dysfunction underlies poor prognosis in Fusobacterium-infected colorectal cancer [normal colon tissue]

Project description:Secretory IgA dysfunction underlies poor prognosis in Fusobacterium-infected colorectal cancer [normal colon tissue]

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Secretory IgA binding to FCRL3 triggers shared inflammatory cytokine secretion by human regulatory T cells and effector T cells

Project description:Several human lymphocyte subsets express the novel secretory IgA receptor FCRL3. Secretory IgA binding to FCRL3 mAb diminishes the inhibitory capacity of regulatory T cells and promotes a Th17-like phenotype. Here we report that in CD4+ regulatory T cells and CD8+ terminal effector T cells secretory IgA induced a shared inflammatory gene signature that included PTGS2 encoding COX2, and the prototypic inflammatory cytokine genes IL1A, IL1B, and IL8. Secretory IgA in regulatory T cells also elevated gene transcripts required for lineage identity and function. Secretory IgA promoted IL-1β, IL-6, IL-8, IL-10, IFN-γ, and TNF-α protein secretion by both T cell types. . We propose that secretory IgA provokes in regulatory and effector T cells a coordinated inflammatory response to facilitate mucosal pathogen clearance.

2025-04-07 | GSE277028 | GEO

Multiple myeloma immunoglobulin lambda translocations portend poor prognosis

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Apyrase-mediated amplification of secretory IgA promotes intestinal homeostasis

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A Group of Highly Secretory miRNAs Correlates with Lymph Node Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma

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Distinct gene expression profile between ARID1Ahigh and good prognosis and ARID1Alow and poor prognosis groups

Project description:Distinct gene expression profile between ARID1Ahigh and good prognosis and ARID1Alow and poor prognosis groups

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Distinct gene expression profile between ARID1Ahigh and good prognosis and ARID1Alow and poor prognosis groups

Project description:Cancer tissue specimens from ARID1Ahigh and good prognosis and ARID1Alow and poor prognosis of patients with advanced gastric cancer were extracted and analyzed.

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Elevated PRKD2 Promotes Progression and Poor Prognosis of Multiple Myeloma

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