Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Melanoma plasticity is regulated by mTOR-mediated crosstalk between MITF and TFE3

ABSTRACT: Melanoma plasticity is regulated by mTOR-mediated crosstalk between MITF and TFE3

PROVIDER: PRJNA1143400 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR30111840_1.fastq.gz	Fastqsanger.gz
	SRR30111840_2.fastq.gz	Fastqsanger.gz
	SRR30111841_1.fastq.gz	Fastqsanger.gz
	SRR30111841_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 109

Similar Datasets

Melanoma plasticity is regulated by mTOR-mediated crosstalk between MITF and TFE3

Project description:Melanoma plasticity is regulated by mTOR-mediated crosstalk between MITF and TFE3

| PRJNA1143060 | ENA

Melanoma plasticity is regulated by mTOR-mediated crosstalk between MITF and TFE3

Project description:Bulk RNAseq was performed to identify differences in gene expression in SKMEL28 cells as related to MITF and TFE3 expression.

2025-03-20 | GSE273789 | GEO

Melanoma plasticity is regulated by mTOR-mediated crosstalk between MITF and TFE3

Project description:ATAC-seq performed to identify chromatin accessibility across the genome. CUT&RUN-seq was performed to identify and compare transcription factor and histone mark occupancy across genome of WT and MITF and TFE3 KO cells.

2025-03-20 | GSE273815 | GEO

Transcriptional regulation of the innate immune reponse by the MITF/TFE3 family

Project description:To understand the activation of the MITF/TFE transcription factors in effective defense against pathogens we examined the genome wide distribution of TFE3 in control and activated mouse macrophages. It was determined that TFEB and TFE3 collaborate with each other to promote efficient autophagy induction, increased lysosomal biogenesis, and transcriptional upregulation of proinflammatory cytokines and key mediators of the inflammatory response. 4 samples were analyzed: Background Control, Control, Starvation, LPS

2016-02-01 | E-GEOD-75822 | biostudies-arrayexpress

Transcriptional regulation of the innate immune reponse by the MITF/TFE3 family

2016-02-01 | GSE75822 | GEO

Antagonistic Roles for MITF and TFE3 in Melanoma Plasticity.

Project description:Melanoma cells have the ability to switch from a melanocytic and proliferative state to a mesenchymal and invasive state and back again. This plasticity drives intra-tumoral heterogeneity, progression, and therapeutic resistance. Microphthalmia-associated Transcription Factor (MITF) promotes the melanocytic/proliferative phenotype, but factors that drive the mesenchymal/invasive phenotype and the mechanisms that effect the switch between cell states are unclear. Here, we identify the MITF paralog TFE3 and the non-canonical mTORC1 pathway as regulators of the mesenchymal state. We show that TFE3 expression drives the metastatic phenotype in melanoma cell lines and tumors. Deletion of TFE3 in MITF-low melanoma cell lines suppresses their ability to migrate and metastasize. Further, MITF suppresses the mesenchymal phenotype by directly or indirectly activating expression of FNIP1, FNIP2, and FLCN, which encode components of the non-canonical mTORC1 pathway, thereby promoting cytoplasmic retention and lysosome-mediated degradation of TFE3. These findings highlight a molecular pathway controlling melanoma plasticity and invasiveness.

| S-EPMC11257520 | biostudies-literature

The crosstalk between MYC and mTOR during osteoclastogenesis

Project description:The crosstalk between MYC and mTOR during osteoclastogenesis

| PRJNA837771 | ENA

DETECTION OF FOUR NOVEL RENAL TUMORS CASES HARBORING RBM10-TFE3 FUSIONS

Project description:Microphtalmia-associated-transcriptional-factor-family translocation renal cell carcinoma (MiTF-tRCC) currently includes two main subtypes: “TFEB-tRCC” most often characterized by a t(6;11)(p21;q13) that generates a fusion of TFEB with MALAT1 and “TFE3-tRCC” characterized by rearrangements of TFE3 at Xp11.23 (2-3) that produce a variety of fusion genes. FISH is a handy method in routine practice that allows the detection of a rearrangement of TFE3. However, it reaches its limits in cases of micro-inversions or insertions: in fact paracentric microinversions that involve GRIPAP1 (Xp11.23) (23, Classe) or RBM10 (Xp11.3), very close to TFE3 , are most often undetectable.We report the clinical, immunohistological, genomic and molecular description of four novel TFE3-tRCC with RBM10-TFE3 fusion detected by targeted RNASeq analysis that illustrate the difficulties of diagnosis, especially in reason of disconcerting negative TFE3 FISH results.

2020-11-04 | GSE160731 | GEO

Mitf

Project description:Drosophila melanogaster Mitf, Mitf, is expressed in 3 baseline experiment(s);

| FBgn0263112 | ExpressionAtlas

Mitf

Project description:Drosophila melanogaster Mitf, Mitf, is differentially expressed in 13 experiment(s);

| FBgn0263112 | ExpressionAtlas