Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

An engineered ovarian somatic organoid model exhibits age-dependent changes in cellular organization and function

ABSTRACT: An engineered ovarian somatic organoid model exhibits age-dependent changes in cellular organization and function

PROVIDER: PRJNA1143554 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR30115967.fastq.gz	Fastqsanger.gz
	SRR30115968.fastq.gz	Fastqsanger.gz
	SRR30115969.fastq.gz	Fastqsanger.gz
	SRR30115970.fastq.gz	Fastqsanger.gz
	SRR30115971.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

An engineered ovarian somatic organoid model exhibits age-dependent changes in cellular organization and function

Project description:Ovarian somatic cells are essential for tissue function, but there are no ex vivo models which maintain the cellular heterogeneity, in addition to the cell-cell and cell-matrix interactions of this compartment. We engineered a novel ovarian somatic organoid model in which a stroma-enriched fraction of primary mouse ovarian somatic cells was cultured in scaffold-free agarose micromolds. We sought to use this ovarian somatic organoid model to investigate mechanisms of ovarian aging and performed single cell RNA sequencing using primary ovarian somatic cells isolated from reproductively young and old mice, as well as organoids generated from young and old mice at days 1 and 6 of culture to assess age-dependent changes to cellular composition.

2024-08-02 | GSE273891 | GEO

Somatic embryogensis of Vitis vinifera exhibits a transcriptomic hourglass pattern

Project description:Somatic embryogensis of Vitis vinifera exhibits a transcriptomic hourglass pattern

| PRJNA980588 | ENA

Self-organization and symmetry breaking in intestinal organoid development

Project description:Self-organization and symmetry breaking in intestinal organoid development

| PRJNA476588 | ENA

Cell Fate Control by Engineered Chromatin Regulator

Project description:MS analysis to provide insights into proteins bound to engineered cell fate regulator NanogBiD during somatic cell reprogramming

2023-10-09 | PXD046008 |

Self-organization and symmetry breaking in intestinal organoid development [scRNA-Seq]

Project description:Self-organization and symmetry breaking in intestinal organoid development [scRNA-Seq]

| PRJNA476590 | ENA

scRNA-seq for E16.5 intestinal epithelial cells grown in conventional organoid cultures or as engineered tissues

Project description:As part of our characterization of cellular complexity within our in vitro cultures, we performed scRNA-seq experiments analysing mouse E16.5 intestinal epithelial cells cultured 1) in conventional organoid cultures 3D or 2) as engineered tissues on microfabricated hydrogel scaffolds. We identified 6 transcriptionally disting clusters of both, fetal and adult identity highlighting the cellular complexity within our in vitro models.

2025-11-01 | GSE247255 | GEO

Self-organization and symmetry breaking in intestinal organoid development [bulk RNA-Seq]

Project description:Self-organization and symmetry breaking in intestinal organoid development [bulk RNA-Seq]

| PRJNA476589 | ENA

Gene expression analysis of patient-derived engineered organoid model of thyroid cancer (TC)

Project description:Gene expression analysis of patient-derived engineered organoid model of thyroid cancer (TC)

| PRJNA1257792 | ENA

RNA-sequencing of genetically engineered intestinal organoid lines modeling colorectal cancer (CRC) progression

Project description:RNA-sequencing of genetically engineered intestinal organoid lines modeling colorectal cancer (CRC) progression

| PRJNA1000918 | ENA

ATAC-sequencing of genetically engineered intestinal organoid lines modeling colorectal cancer (CRC) progression

Project description:ATAC-sequencing of genetically engineered intestinal organoid lines modeling colorectal cancer (CRC) progression