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Genome-wide mapping of H3K9me3 in platinum sensitive and resistant epithelial ovarian cancer cell lines.

ABSTRACT: Genome-wide mapping of H3K9me3 in platinum sensitive and resistant epithelial ovarian cancer cell lines.

PROVIDER: PRJNA1143574 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30117156_1.fastq.gz	Fastqsanger.gz
	SRR30117156_2.fastq.gz	Fastqsanger.gz
	SRR30117157_1.fastq.gz	Fastqsanger.gz
	SRR30117157_2.fastq.gz	Fastqsanger.gz
	SRR30117158_1.fastq.gz	Fastqsanger.gz

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Genome-wide mapping of H3K9me3 in platinum sensitive and resistant epithelial ovarian cancer cell lines.

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Project description:Resistance to platinum-based chemotherapy is a clinical challenge in the treatment of ovarian cancer (OC) and limits survival. Therefore, innovative drugs against platinum-resistance are urgently needed. Our therapeutic concept is based on the conjugation of two chemotherapeutic compounds to a monotherapeutic pro-drug, which is taken up by cancer cells and cleaved into active cytostatic metabolites. Here, we explore the activity of the duplex-prodrug 5-FdU-ECyd, covalently linking 2'-deoxy-5-fluorouridine (5-FdU) and 3'-C-ethynylcytidine (ECyd), on platinum-resistant OC cells. RNA-Sequencing was used for characterization of 5-FdU-ECyd treated platinum-sensitive A2780 and isogenic platinum-resistant A2780cis.

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