Project description:SUMMARY Non-Hispanic Black/African American (Black/AA) men in the United States have disproportionally higher incidence and mortality rates of lung cancer compared to non-Hispanic White (NHW) men. Biological factors are believed to play critical roles in driving the disparities. Nevertheless, large-scale genomic studies fail to identify significant somatic differences in lung cancer driver genes contributing to the disparities. Elevated expression of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis is observed in many cancer types. Here, we observed a higher PRMT6 expression in lung cancer of Black/AA men compared to NHW men. PRMT6 formed a heteromer complex with PRMT1 to catalyze arginine methylation of interleukin enhancer-binding factor 2 essential for cell proliferation. Disrupting PRMT1/PRMT6 heteromer complex by a competitive peptide reduced cell proliferation in non-small cell lung cancer cell lines and lung cancer patient-derived organoids. This work implicates that PRMT1/PRMT6 heteromer complex contributes to poorer lung cancer outcomes in Black/AA men vs. NHW men that could serve as a target to eliminate cancer health disparities.

2023-12-15 | MSV000093674 | MassIVE

HOPE-Genomics Intervention for the Improvement of Cancer Patient Knowledge of Genomics

Project description:This clinical trial studies the effectiveness of a web-based cancer education tool called Helping Oncology Patients Explore Genomics (HOPE-Genomics) in improving patient knowledge of personal genomic testing results and cancer and genomics in general. HOPE-Genomics is a web-based education tool that teaches cancer/leukemia patients, and patients who may be at high-risk for developing cancer, about genomic testing and provide patients with information about their own genomic test results. The HOPE-Genomics tool may improve patient’s genomic knowledge and quality of patient-centered care. In addition, it may also improve education and care quality for future patients.

| 2378933 | ecrin-mdr-crc

Understanding determinants of racial disparities in lung cancer incidence

Project description:Understanding determinants of racial disparities in lung cancer incidence

| PRJNA1165826 | ENA

Understanding determinants of racial disparities in lung cancer incidence

Project description:Understanding determinants of racial disparities in lung cancer incidence

| PRJNA1165824 | ENA

Characterisation of VDR signaling in prostate cancer health disparities

Project description:Characterisation of VDR signaling in prostate cancer health disparities

| PRJNA925935 | ENA

Genomics of Prostate Cancer

Project description:Genomics of Prostate Cancer