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RNA m1A methyltransferase TRMT61A induces MAPK/ERK signaling and is a therapeutic target in colorectal cancer [MeRIP-Seq]

ABSTRACT: RNA m1A methyltransferase TRMT61A induces MAPK/ERK signaling and is a therapeutic target in colorectal cancer [MeRIP-Seq]

PROVIDER: PRJNA1144905 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30148329_1.fastq.gz	Fastqsanger.gz
	SRR30148329_2.fastq.gz	Fastqsanger.gz
	SRR30148330_1.fastq.gz	Fastqsanger.gz
	SRR30148330_2.fastq.gz	Fastqsanger.gz
	SRR30148331_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

RNA m1A methyltransferase TRMT61A induces MAPK/ERK signaling and is a therapeutic target in colorectal cancer [MeRIP-Seq]

Project description:The role of N1-methyladenosine (m1A) in cancer remains poorly understood. Here we investigate the functional importance of RNA m1A methyltransferase TRMT61A in colorectal cancer (CRC) and assess its potential as a therapeutic target. Our findings demonstrate consistent elevation of TRMT61A expression and RNA m1A levels in primary CRC tissues, which correlate significantly with poor patient survival. Through CRISPR/Cas9 screenings, TRMT61A is the most essential gene among m1A regulators. We further elucidate that TRMT61A facilitates CRC tumorigenesis and progression by enhancing the stability of mRNA of crucial targets, including ONECUT2, thereby activating the MAPK/ERK signaling pathway in an m1A-dependent manner. Of note, we show promising anti-CRC effects by inhibiting TRMT61A using nanoparticleencapsulated siTRMT61A or our identified small molecule compound, PGG. Collectively, our study uncovers the essential role of TRMT61A-m1A in CRC by activating the ONECUT2-MAPK/ERK pathway. Targeting TRMT61A holds promise as a therapeutic approach for treating CRC.

2025-02-01 | GSE274076 | GEO

RNA m1A methyltransferase TRMT61A induces MAPK/ERK signaling and is a therapeutic target in colorectal cancer II

2025-02-01 | GSE274028 | GEO

RNA m1A methyltransferase TRMT61A induces MAPK/ERK signaling and is a therapeutic target in colorectal cancer I

2025-02-01 | GSE274027 | GEO

RNA m1A methyltransferase TRMT61A induces MAPK/ERK signaling and is a therapeutic target in colorectal cancer [Ribo-Seq]

2025-02-01 | GSE274079 | GEO

RNA m1A methyltransferase TRMT61A induces MAPK/ERK signaling and is a therapeutic target in colorectal cancer II

Project description:RNA m1A methyltransferase TRMT61A induces MAPK/ERK signaling and is a therapeutic target in colorectal cancer II

| PRJNA1144484 | ENA

RNA m1A methyltransferase TRMT61A induces MAPK/ERK signaling and is a therapeutic target in colorectal cancer I

Project description:RNA m1A methyltransferase TRMT61A induces MAPK/ERK signaling and is a therapeutic target in colorectal cancer I

| PRJNA1144485 | ENA

RNA m1A methyltransferase TRMT61A induces MAPK/ERK signaling and is a therapeutic target in colorectal cancer [Ribo-Seq]

Project description:RNA m1A methyltransferase TRMT61A induces MAPK/ERK signaling and is a therapeutic target in colorectal cancer [Ribo-Seq]

| PRJNA1144916 | ENA

Comprehensive Transcriptomic Analysis of DLD1 Colon Cancer Cells Overexpressing TRMT6 and TRMT61A Genes [RNA-seq]

Project description:This study investigates the transcriptomic changes in DLD1 colon cancer cells upon overexpression of TRMT6 and TRMT61A genes, with a focus on identifying downstream genes associated with tumor cell senescence. We performed RNA-seq, tRNA m1A-MeRIP-seq, and ribo-seq on DLD1 cells overexpressing TRMT6 and TRMT61A, as well as control cells, each with two biological replicates. The integrated analysis of these sequencing data aims to elucidate the molecular mechanisms underlying the regulation of tumor cell senescence by TRMT6 and TRMT61A.

2026-03-11 | GSE290123 | GEO

Comprehensive Transcriptomic Analysis of DLD1 Colon Cancer Cells Overexpressing TRMT6 and TRMT61A Genes [RNA methylation]

2026-03-11 | GSE290126 | GEO

tRNA m1A modification enhances anti-tumor immunity in macrophages by promoting translation of key interferon associated genes [BMDMs bulk RNA-seq]

Project description:The involvement of tRNA m1A modification in the anti-tumoral tumor-associated macrophages (TAMs) has been validated in our study that macrophage-specific knockout of m1A “writer” enzymes TRMT61A leads to increased infiltration of TAMs, impaired CD8+ T cell function, and enhanced tumor growth. Since TRMT61A-derived tRNA m1A modification mainly enhances translation efficiency, we reasoned that the loss of TRMT61A in macrophages would result in the downregulation of a group of protein levels without affecting their mRNA levels. To assess the impact of TRMT61A deficiency on mRNA transcript levels in macrophages, we collected TRMT61A-KO and WT BMDMs derived from Trmt61af/fLysmCre and Trmt61af/f mice to perform bulk RNA sequencing. Of total 22173 genes, the mRNA expression of 22054 genes remain unchanged in macrophages upon TRMT61A deletion, suggesting that TRMT61A did not contribute to mRNA transcriptional regulation in macrophages.

2026-03-04 | GSE239601 | GEO

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