Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Precise modulation of mSWI/SNF identified dosage-sensitive chromatin regulation [RNA-Seq]

ABSTRACT: Precise modulation of mSWI/SNF identified dosage-sensitive chromatin regulation [RNA-Seq]

PROVIDER: PRJNA1146038 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR30178057_1.fastq.gz	Fastqsanger.gz
	SRR30178057_2.fastq.gz	Fastqsanger.gz
	SRR30178058_1.fastq.gz	Fastqsanger.gz
	SRR30178058_2.fastq.gz	Fastqsanger.gz
	SRR30178059_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Precise modulation of mSWI/SNF identified dosage-sensitive chromatin regulation

Project description:Precise modulation of mSWI/SNF identified dosage-sensitive chromatin regulation

| PRJNA1146458 | ENA

Precise modulation of mSWI/SNF identified dosage-sensitive chromatin regulation [RNA-Seq]

Project description:ATP-dependent chromatin remodelers establish and arrange nucleosome distribution, modifying accessibility of DNA. Brg1 is exclusive ATPase subunit of mSWI/SNF complex. To understand the dosage dependent function of mSWI/SNF complex. We take an advantage of dTag system to precisely control abundancy of BRG1. We found overall Brg1-binding is sensitive to its abundance nevertheless OCT4-target or H3K27ac region, suggesting Brg1 genome-wide distribution rather than being actively recruited. We also reveal open chromatin dependency on BRG1. The chromatin accessibility of super enhancer shows buffered response on depletion of BRG1, whereas weak enhancer is sensitive. Finally, transcriptomic analysis identified that transcription shows buffered dependencies on BRG1 loss. Overall, our results highlight kinetics differences of BRG1-binding to transcriptome underline BRG1 dosage-sensitive mechanism.

2025-01-01 | GSE274356 | GEO

Precise modulation of mSWI/SNF identified dosage-sensitive chromatin regulation [CUT&Run]

2025-01-01 | GSE274358 | GEO

Precise modulation of mSWI/SNF identified dosage-sensitive chromatin regulation [ATAC-Seq]

2025-01-01 | GSE274357 | GEO

Precise modulation of mSWI/SNF identified dosage-sensitive chromatin regulation (human cell)

2025-05-05 | GSE294015 | GEO

Precise modulation of mSWI/SNF identified dosage-sensitive chromatin regulation [CUT&Run]

Project description:Precise modulation of mSWI/SNF identified dosage-sensitive chromatin regulation [CUT&Run]

| PRJNA1146040 | ENA

Precise modulation of mSWI/SNF identified dosage-sensitive chromatin regulation (human cell)

Project description:Precise modulation of mSWI/SNF identified dosage-sensitive chromatin regulation (human cell)