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Aging promotes reactivation of the Barr body at distal chromosome regions [snRNA]

ABSTRACT: Aging promotes reactivation of the Barr body at distal chromosome regions [snRNA]

PROVIDER: PRJNA1147674 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30223485_1.fastq.gz	Fastqsanger.gz
	SRR30223485_2.fastq.gz	Fastqsanger.gz
	SRR30223486_1.fastq.gz	Fastqsanger.gz
	SRR30223486_2.fastq.gz	Fastqsanger.gz
	SRR30223487_1.fastq.gz	Fastqsanger.gz

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Aging promotes reactivation of the Barr body at distal chromosome regions [snRNA]

Project description:Decades ago, evidence of age-related reactivation of a single gene on the female inactive X chromosome was observed in mice. While stable silencing of the Barr body is crucial for balancing gene dosage between sexes, it remained unclear whether silencing is maintained during aging. Here, we employed allele-specific multi-omics approaches to capture a comprehensive catalog of genes escaping X chromosome inactivation throughout mouse development and aging. We found substantially elevated escape rates during aging across organs, occurring in multiple distinct cell types and concentrated at distal chromosome regions. Consistently, chromatin accessibility was increased across multiple megabases at chromosome ends, affecting regulatory elements of escapees. Since several age-specific escapees are linked to human diseases, their elevated expression in females might contribute to sex-biased disease progression observed during aging.

2025-03-21 | GSE274692 | GEO

Aging promotes reactivation of the Barr body at distal chromosome regions

Project description:Aging promotes reactivation of the Barr body at distal chromosome regions

| PRJNA1147666 | ENA

Aging promotes reactivation of the Barr body at distal chromosome regions [ATAC]

2025-03-21 | GSE274694 | GEO

Aging promotes reactivation of the Barr body at distal chromosome regions [ATAC]

Project description:Aging promotes reactivation of the Barr body at distal chromosome regions [ATAC]

| PRJNA1147677 | ENA

Aging promotes reactivation of the Barr body at distal chromosome regions [RNA organs]

2025-03-21 | GSE274689 | GEO

Aging promotes reactivation of the Barr body at distal chromosome regions [RNA organs]

Project description:Aging promotes reactivation of the Barr body at distal chromosome regions [RNA organs]

| PRJNA1147659 | ENA

Aging promotes reactivation of the Barr body at distal chromosome regions [RNA Major cardiac cell types]

2025-03-21 | GSE274690 | GEO

Aging promotes reactivation of the Barr body at distal chromosome regions [RNA Major cardiac cell types]

Project description:Aging promotes reactivation of the Barr body at distal chromosome regions [RNA Major cardiac cell types]

| PRJNA1147669 | ENA

Aging promotes reactivation of the Barr body at distal chromosome regions

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-03-21 | GSE274695 | GEO

Increased RNA Polymerase Activity at CTCF binding sites on the Epstein Barr Virus Genome During Reactivation from Latency

Project description:We used Precision Nuclear Run-on followed by Deep Sequencing (PRO-Seq) to investigate RNA Polymerase (Pol) activity during Epstein-Barr Virus (EBV) reactivation in EBV positive Burkitt's lymphoma cell lines Mutu-I and Akata. Nuclei were harvested from latent cells and after treatment with NaB/TPA (Mutu-I) or anti-IgG (akata) to stimulate reactivation at 1 and 4 and 12h. We identified multiple sites on the EBV genome enriched with Pol displaying distinct patterns of activity, which showed an association with CTCF and open chromatin.

2023-01-06 | GSE188584 | GEO

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