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ATAC-seq profiling of MORC2 knock-out HEK293T cells

ABSTRACT: ATAC-seq profiling of MORC2 knock-out HEK293T cells

PROVIDER: PRJNA1147785 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR30227233_1.fastq.gz	Fastqsanger.gz
	SRR30227233_2.fastq.gz	Fastqsanger.gz
	SRR30227234_1.fastq.gz	Fastqsanger.gz
	SRR30227234_2.fastq.gz	Fastqsanger.gz
	SRR30227235_1.fastq.gz	Fastqsanger.gz

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Project description:We report an in vitro reconstitution of full-length MORC2, the most commonly mutated MORC member, linked to various cancers and neurological disorders. MORC2 possesses multiple DNA binding sites that undergo structural rearrangement upon DNA binding. MORC2 locks onto the DNA using its C-terminal domain (CTD) and acts as a sliding clamp. A conserved phosphate-interacting motif within the CTD was found to regulate ATP hydrolysis and cooperative DNA binding. Importantly, MORC2 mediates chromatin remodelling via ATP hydrolysis-dependent DNA compaction, regulated by the phosphorylation state of its CTD.

2025-05-05 | GSE274771 | GEO